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Surg-38. direct evidence of plasticity within primary motor and sensory cortices via direct electrical stimulation in glioblastoma patients undergoing repeat awake craniotomy
In this study, we examine plasticity within primary sensory (S1) and motor (M1) cortices in glioblastoma patients undergoing repeat intra-operative direct electrical stimulation (DES) under awake conditions.METHODS:This retrospective analysis included five patients with glioblastoma in/near M1/S1 that underwent two awake surgeries, each with DES-based sensory and motor mapping. Inter-surgery interval was 216 ± 41 days. Plasticity was defined as a change in mapping result (gain, loss, or change of function) within M1/S1 at second operation or absence of typical mapping result without a change in the patient&rsqu...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Gibb, W., Kong, N. Tags: SURGICAL THERAPY Source Type: research

Ntox-08. safety of intra-arterial chemotherapy in the treatment of brain tumours
The treatment of brain tumors is greatly limited the delivery impediment caused by the blood-brain barrier and blood-tumor barrier. To circumvent this limitation, different approaches have been studied, including intra-arterial delivery. Because of a significant local increase in plasma-peak concentration, this strategy increases the local area under the curve, and translates into a 3 to 5.5 fold increase in intra-tumoral chemotherapy concentration. However, intra-arterial chemotherapy in the treatment of brain tumors has a notoriously bad name, thanks to prior trials led in past decades showing significant neurotoxicities...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Fortin, D., Caux, S., Gahide, G. Tags: NEUROTOXICITY OF THERAPY Source Type: research

Ntox-11. recurrent episodes of stroke-like migraine attacks after radiation therapy (smart) syndrome in adults
We report two cases of multiply-recurrent SMART syndrome, one autopsy-documented. Case 1 is a 46 year old woman with an atypical meningioma treated with resection and radiation who presented sixteen months after completion of radiation with sudden onset hemiparesis and dysarthria. Brain MRI showed the typical gyriform enhancement seen in SMART syndrome. No other attributable disorders were found on extensive workup, and both symptoms and radiographic abnormalities resolved over several weeks without further therapies. Six months later she again presented with identical symptoms and MRI findings. Incomplete resolution ...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Mohler, A., Kleinschmidt-DeMasters, B. K., Damek, D. Tags: NEUROTOXICITY OF THERAPY Source Type: research

P05.04 Morphine pretreatment improves the therapeutic efficacy of doxorubicin in an orthotopic model of human glioblastoma
Conclusions:The present findings show that molecules as morphine are able to interfere with molecules normally unable to cross the BBB. This mechanism could be used for new approaches in therapy of refractory CNS tumors as glioblastoma.
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Da Ros, M. Tags: P05 In vitro / in vivo models Source Type: research

P08.46 Rechallenge with bevacizumab in a long-term survivor with glioblastoma
The prognosis of patients with glioblastoma multiforme (GBM, WHO grade IV), the most common primary brain tumor in adults, is generally poor with median survival of less than one year in untreated patients and approximately 15 months following standard of care therapy. However, 10 % survival at 5 years was observed in a randomized phase III study. At GBM recurrence, the addition of bevacizumab (BEV), a humanized monoclonal antibody against circulating vascular endothelial growth factor (VEGF), resulted in a 3–4 month prolongation of progression-free survival (PFS) without improving overall survival (OS...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Koeppen, S., Hense, J. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research

Bm-12 * cerebral infarction secondary to pulmonary vein compression and left atrial appendage tumor infiltration as the presenting sign of metastatic squamous cell carcinoma of the base of the tongue
CONCLUSION: Cardiac metastases are rare and non-myxomatous tumor embolization to the brain even rarer especially in the setting of cerebral infarction due to pulmonary vein thrombus. Here we describe a case of multiple acute cerebral infarctions appearing from a proximal source refractory to anticoagulation. Thromboembolism from the pulmonary vein and tumor embolization from cardiac metastases are the likely mechanisms for his clinical presentation and radiographic findings. This case demonstrates the complexity of multiple stroke etiologies in one patient and the importance of cardiac imaging in stroke evaluation, particu...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Dredla, B., Siegel, J., Jaeckle, K. Tags: BRAIN METASTASES (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Bm-19 * symptomatic and economic burden of brain metastases in patients with alk+ nsclc
CONCLUSIONS: BM presents a substantial symptomatic and economic burden in patients with ALK+ NSCLC. Given the large percentage of ALK+ NSCLC patients who will eventually develop BM, this highlights an important unmet need.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Macalalad, A., Sasane, M., Zhang, J., Culver, K., Dea, K., Nitulescu, R., Wu, E., Guerin, A. Tags: BRAIN METASTASES (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Rm-02 * long-term survival in glioblastoma patients following stroke: a non-consecutive case series
CONCLUSION: Long-term survival with glioblastoma is uncommon, particularly following recurrence, and particularly in the absence of ongoing treatment. Though stroke is in general a poor prognostic factor for patients with glioblastoma, here we highlight the possibility that the acute vascular disruption that results from strokes can occasionally arrest tumor growth. Although endovascular embolization is unlikely to ever be considered an appropriate treatment for glioblastoma, these findings support the notion that vascular disrupting agents and endovascular therapies that are limited to a single vascular territory may have...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Hu, J., Phuphanich, S., Fan, X., Rudnick, J., Prasad, R. Tags: RESISTANCE/RECURRENCE MECHANISMS Source Type: research

Rt-08 * proton therapy (pt) large-volume re-irradiation for recurrent glioma: overall survival (os) and toxicity outcomes
CONCLUSION: Large-volume PT re-irradiation for recurrent glioma is safe and associated with promising OS outcomes, particularly in the setting of bevacizumab-refractory tumors.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Desai, B., Rockne, R., Rademaker, A., Raizer, J., Paleologos, N., Merrell, R., Grimm, S., Azeem, S., Hartsell, W., Sweeney, P., Swanson, K., Gondi, V. Tags: RADIATION THERAPY (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Nc-01 * attentional and language functioning in adult patients with glioma: a voxel-based lesion-symptom mapping study
CONCLUSION: These findings identify some of the key anatomic structures involved in attentional and language functioning in adult patients with glioma using an innovative lesion analysis technique.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Banerjee, P., Leu, K., Harris, R., Cloughesy, T., Bookheimer, S., Liau, L., Nghiemphu, P., Lai, A., Ellingson, B. Tags: NEURO-COGNITIVE AND FUNCTIONAL OUTCOMES Source Type: research

Cn-15 * adverse effects of bevacizumab in brain tumor patients
CONCLUSION: The range of toxicities was similar to other reports. Interestingly, hypertension was the most common adverse effect and was often not treated. The high incidence of lymphocytopenia may have implications for combination with immunotherapies. These findings underscore the need to develop predictive models to identify patients at high risk for serious treatment-related toxicities.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Pawar, T., Ladha, H., Mandel, J., Gilbert, M., O'Brien, B., Hamza, M., Armstrong, T. Tags: COMPLICATIONS OF THERAPY AND NEUROTOXICITY Source Type: research