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Thrombolysis for Ischemic Stroke in Patients with Brain Tumors
Conclusions: In summary, very limited data exist about thrombolysis in patients with brain tumors. Differentiation of tumor by additional neuroimaging before thrombolysis in ischemic stroke is recommended as thrombolysis might be considered in extra-axial benign appearing neoplasms (eg, meningioma) but is not advisable in intra-axial primary or metastatic neoplasm. Further reporting of thrombolysis in patients with brain tumors is recommended.
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2013 Category: Neurology Authors: Thorleif Etgen, Ines Steinich, Lukas Gsottschneider Tags: Original Articles Source Type: research

Fatal Intracranial Hemorrhage after Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Associated with Cancer-related Nonbacterial Thrombotic Endocarditis
Nonbacterial thrombotic endocarditis (NBTE) is associated with hypercoagulability in patients with inflammatory states such as cancer and autoimmune diseases. Cardiac vegetations caused by NBTE often lead to life-threatening systemic thromboembolism that most frequently affects the brain, spleen, and kidneys. A 54-year-old woman diagnosed with ovarian cancer suddenly developed back pain and left hemiparesis. Although intravenous alteplase (rt-PA) therapy was administered to treat hyperacute ischemic infarction detected by magnetic resonance imaging, intracranial hemorrhage occurred in the left hemisphere several hours late...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Takuya Yagi, Kie Takahashi, Mariko Tanikawa, Morinobu Seki, Takato Abe, Norihiro Suzuki Tags: Case Reports Source Type: research

Lacunar Stroke, Cavernous Angioma, and Fusiform Aneurysm Due to Irradiation for Pilocytic Astrocytoma —A Case Report
We describe a rare case of a pediatric patient who presented multiple different types of vascular events consecutively in the irradiated field including lacunar stroke because of occlusion of perforating artery, intraventricular hemorrhage from cavernoma, and subarachnoid hemorrhage because of the rupture of fusiform aneurysm, 6 years after radiotherapy against pilocytic astrocytoma.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2018 Category: Neurology Authors: Maruyama Kunitaka, Takuya Akai, Naoki Akioka, Takahiro Tomita, Shoichi Nagai, Satoshi Kuroda Tags: Case Studies Source Type: research

Intratumoral Hemorrhage in a Patient with Malignant Meningioma under Anticoagulant Therapy
We report the case of an elderly woman with malignant meningioma and atrial fibrillation who started taking anticoagulants after an ischemic stroke and subsequently developed intratumoral hemorrhage. Further studies are required to confirm whether a particular anticoagulant agent is suitable for patients with brain tumor and atrial fibrillation.
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2015 Category: Neurology Authors: Yasuyuki Ito, Makoto Nakajima, Mari Watari, Tetsuro Sakamoto, Yoichiro Hashimoto, Seiji Tajiri, Akira Takada, Yukio Ando Tags: Case Report Source Type: research

Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats
Conclusions: The present study demonstrates that rosuvastatin pretreatment ameliorates EBI after SAH through the attenuation of oxidative stress and NF-κB–mediated inflammation.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2014 Category: Neurology Authors: Ken Uekawa, Yu Hasegawa, Mingjie Ma, Takashi Nakagawa, Tetsuji Katayama, Daisuke Sueta, Kensuke Toyama, Keiichiro Kataoka, Nobutaka Koibuchi, Takayuki Kawano, Jun-ichi Kuratsu, Shokei Kim-Mitsuyama Tags: Original Articles Source Type: research

Intracerebral Hemorrhage Outcomes in Patients with Systemic Cancer
Single-center studies suggest that patients with cancer have similar outcomes after intracerebral hemorrhage (ICH) compared to patients without cancer. However, these studies were limited by small sample sizes and high rates of intratumoral hemorrhage. Our hypothesis was that systemic cancer patients without brain involvement fare worse after ICH than patients without cancer.
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2016 Category: Neurology Authors: Santosh B. Murthy, Aditi Shastri, Alexander E. Merkler, Daniel F. Hanley, Wendy C. Ziai, Matthew E. Fink, Costantino Iadecola, Hooman Kamel, Babak B. Navi Source Type: research

Risk of intracranial hemorrhage with direct oral anticoagulation versus low molecular weight heparin in the treatment of brain tumor-associated venous thromboembolism: A meta-analysis
Direct oral anticoagulants (DOACs) are effective in treating cancer-related thrombosis and are superior to low molecular weight heparin (LMWH) in terms of efficacy. The effects of DOACs or LMWH on intracranial hemorrhage (ICH) remain uncertain in individuals with brain tumors. We conducted a meta-analysis to compare the frequency of ICH in individuals with brain tumors treated with DOACs or LMWH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 4, 2023 Category: Neurology Authors: Jun Yang, Zesong He, Meihua Li, Tao Hong, Taohui Ouyang Source Type: research