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Source: Cancer Control
Cancer: Squamous Cell Carcinoma
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Total 683 results found since Jan 2013.
Role of tissue markers associated with tumor microenvironment in the progression and immune suppression of oral squamous cell carcinoma
Med Oncol. 2023 Sep 20;40(10):303. doi: 10.1007/s12032-023-02169-5.ABSTRACTHead and neck cancers (HNC) continues to dominate major cancers contributing to mortality worldwide. Squamous cell carcinoma is the major type of HNC. Oral Squamous Cell Carcinoma grouped under HNC is a malignant tumor occurring in the oral cavity. The primary risk factors of OSCC are tobacco, alcohol consumption, etc. This review focuses on modulations, mechanisms, growth and differentiation of oral squamous cell carcinoma. Cancer cell surrounds itself with a group of elements forming a favorable environment known as tumor microenvironment (TME). I...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Suganya Ramalingam Sivaramakrishnan Shantha Susruthan Muralitharan Uma Sudhakar Harikrishnan Thamizhchelvan Venkatachalam Deepa Parvathi Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
Integration of palliative care in the management of oral squamous cell carcinoma
Bioinformation. 2023 Jan 31;19(1):1-4. doi: 10.6026/97320630019001. eCollection 2023.ABSTRACTOral Squamous cell Cancers (OSCC) is strongly associated with tobacco consumption. We here in present a case study of a OSCC patient who refused standard oncological care (SOC), to highlight the importance of integrating palliative care (PC) for improved patient outcomes. A 61 years male patient, with history of chewing tobacco for more than 20 years and diagnosed to have OSCC for 1.5 years presented with severe anaemia and a cauliflower-like growth (12 x 10 cm) in the left oral cavity and cheek with greenish-yellow discharge. Pus ...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Republica Sridhar Huwait Etimad Peter Natesan Pushparaj Gauthaman Kalamegam Source Type: research
Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis
Cancer Epidemiol. 2023 Sep 14;86:102451. doi: 10.1016/j.canep.2023.102451. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is considered a multifactorial disease and has been associated with microbial infections, although the association with Candida spp. is still controversial. This systematic review focused on clinical trials which evaluated the relation between oral Candida spp colonization and OSCC. PubMed; Scopus; Embase; Web of Science and Scientific Direct were assessed. Independent reviewers conducted the diagram steps. For data extraction the PRISMA protocol was followed. The quality analysis of ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Camilla Olga Tasso T úlio Morandin Ferrisse Anal ú Barros de Oliveira Beatriz Ribeiro Ribas Janaina Habib Jorge Source Type: research
Intracavitary cardiac metastasis of cervical squamous cell carcinoma with immune thrombocytopenia: a rare case report
We present the case of an adult patient diagnosed with cervical cancer and concurrent right ventricular cancer thrombus, accompanied by immune thrombocytopenia (ITP). The patient exhibited resistance to conventional ITP drugs, with suboptimal platelet response. However, upon achieving initial control of the tumor, the patient's platelet counts returned to normal. Notably, the addition of immune checkpoint inhibitors targeting PD-L1 resulted in effective tumor control, accompanied by sustained high platelet levels. Unfortunately, during subsequent anti-tumor therapy, the patient experienced a prolonged platelet rise time, r...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ning Liu Deguan Lv Raydonna Rachel Schneider Hongyan Yang Mingyan Zhang Yanan Liu Meili Sun Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature
CONCLUSIONS: Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.PMID:37714729 | DOI:10.1016/j.riam.2023.05.001
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Muhammed Cihan I şık O ğuz Karcıoğlu G ülşen Hazırolan Dolunay G ülmez Mehmet Ruhi Onur Mehmet Mahir Kunt Sevtap Arikan-Akdagli G ökhan Metan Source Type: research
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
Sci Immunol. 2023 Sep 15;8(87):eadf6717. doi: 10.1126/sciimmunol.adf6717. Epub 2023 Sep 15.ABSTRACTHuman regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs for cancer therapy without affecting immune homeostasis. Identifying pathways that may distinguish tumor-restricted Tregs is important, yet the transcriptional programs that control intratumoral Treg gene expression, and that are distinct from Tregs in healthy tissues, remain largely unknown. We profiled single-cell transcriptomes of CD4+ T cells in ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Feng Shan Anthony R Cillo Carly Cardello Daniel Y Yuan Sheryl R Kunning Jian Cui Caleb Lampenfeld Asia M Williams Alexandra P McDonough Arjun Pennathur James D Luketich John M Kirkwood Robert L Ferris Tullia C Bruno Creg J Workman Panayiotis V Benos Dario Source Type: research
Human parvovirus B19 infection in malignant and benign tissue specimens of different head and neck anatomical subsites
CONCLUSIONS: To sum up, B19V was frequently present in HNSCC tissues of Iranian patients but mostly absent in the adjacent non-tumor tissues as well as oral mucocele lesions, buccal, and nasopharyngeal swabs of healthy subjects. HPV possibly contributes to B19V persistence in HNSCC tissues. Additional research is required to investigate potential etiological or cofactor roles of B19V in the development of HNSCCs.PMID:37710342 | DOI:10.1186/s13027-023-00528-5
Source: Cancer Control - September 14, 2023 Category: Cancer & Oncology Authors: Haniyeh Abuei Sepide Namdari Tahereh Pakdel Fatemeh Pakdel Azadeh Andishe-Tadbir Abbas Behzad-Behbahani Mohammad J Ashraf Parnian Alavi Ali Farhadi Source Type: research
Definitive chemoradiation in vulvar squamous cell carcinoma: outcome and toxicity from an observational multicenter Italian study on vulvar cancer (OLDLADY 1.1)
CONCLUSION: In the context of CRT for LAVC, the present study reports encouraging results even if there is clearly room for further improvements, in terms of both treatment outcomes, toxicity and treatment interruption management.PMID:37700153 | DOI:10.1007/s11547-023-01712-8
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Gabriella Macchia Valentina Lancellotta Martina Ferioli Calogero Cas à Donato Pezzulla Brigida Pappalardi Concetta Laliscia Edy Ippolito Jacopo Di Muzio Alessandra Huscher Francesca Tortoreto Mariangela Boccardi Roberta Lazzari Anna Myriam Perrone France Source Type: research
Personalized Biomarker-Based Umbrella Trial for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: KCSG HN 15-16 TRIUMPH Trial
CONCLUSION: To our knowledge, this study is the first biomarker-driven umbrella trial for platinum-refractory HNSCC using matched molecular targeted agents. We found that NGS-based genomic phenotyping was methodologically feasible and applicable.PMID:37699162 | DOI:10.1200/JCO.22.02786
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Bhumsuk Keam Min Hee Hong Seong Hoon Shin Seong Gu Heo Ji Eun Kim Hee Kyung Ahn Yun-Gyoo Lee Keon-Uk Park Tak Yun Keun-Wook Lee Sung-Bae Kim Sang-Cheol Lee Min Kyoung Kim Sang Hee Cho So Yeon Oh Sang-Gon Park Shinwon Hwang Byung-Ho Nam Sangwoo Kim Hye Ryu Source Type: research
Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders
CONCLUSION: Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD.PMID:37697274 | DOI:10.1186/s12903-023-03316-0
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Huangkai Li Yu Liu Shanxin Zhou Qin Zhou Xi Yang Source Type: research
Development and Validation of the Oxidative Stress Related lncRNAs for Prognosis in Esophageal Squamous Cell Carcinoma
In conclusion, our study demonstrated that a novel oxidative stress-related DElncRNA prognostic model performed favorably in predicting ESCC patient prognosis and benefits personalized clinical applications.PMID:37686677 | DOI:10.3390/cancers15174399
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Xuan Zheng Wei Liu Yingze Zhu Wenyue Kong Xin Su Lanxiang Huang Yishuang Cui Guogui Sun Source Type: research
The prognostic value of lymphatic metastatic size in head and neck squamous cell carcinoma
CONCLUSIONS: Lymphatic metastatic size was an independently prognostic factor in HNSCC, which may assist in postoperative adjuvant treatment decisions.PMID:37682351 | DOI:10.1007/s00405-023-08199-z
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Wenqian Xie Peiliang Lin Zhijuan Li Huan Wan Faya Liang Jianming Fan Lanlan Deng Xiaoming Huang Source Type: research
Prevalence of human papillomavirus infection in abnormal pap smears
CONCLUSION: Our study shows that the percentage of HR-HPV-positive case increases with the severity of cytologic morphology. HPV had 4 times higher positivity in squamous intraepithelial lesion as compared to ASCUS.PMID:37681080 | PMC:PMC10481853 | DOI:10.25259/Cytojournal_8_2021
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Jaya Mishra Sweety Kalantri Vandana Raphael Biswajit Dey Yookarin Khonglah Ananya Das Source Type: research
