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Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration.
Abstract Intracerebral hemorrhage (ICH) is a pathological condition that accompanies certain neurological diseases like hemorrhagic stroke or brain trauma. Its effects are severely destructive to the brain and can be fatal. There is an entire spectrum of harmful factors which are associated with the pathogenesis of ICH. One of them is a massive release of hemin from the decomposed erythrocytes. It has been previously shown, that hemin can inhibit the large-conductance Ca(2+)-regulated potassium channel in the plasma membrane. However, it remained unclear whether this phenomenon applies also to the mitochondrial la...
Source: Experimental Neurology - April 30, 2014 Category: Neurology Authors: Augustynek B, Kudin AP, Bednarczyk P, Szewczyk A, Kunz WS Tags: Exp Neurol Source Type: research