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Transcriptional and Epigenetic Modulation of Human Rhinovirus-Induced CXCL10 Production by Cigarette Smoke.
Abstract Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoking is the primary risk factor for the development of COPD and 25% of asthmatics smoke. Smokers experience both longer and more severe colds. We previously showed that cigarette smoke extract (CSE) inhibited HRV-induced expression of a range of epithelial antiviral molecules. Here, we use CXCL10 as a model antiviral gene to examine the mechanisms by which CSE inhibits epithelial antiviral immunity. HRV-induced CXCL10 transcription depends upon activation of nuclear factor-ĸB (NF-ĸB) an...
Source: American Journal of Respiratory Cell and Molecular Biology - October 15, 2013 Category: Molecular Biology Authors: Hudy MH, Traves SL, Proud D Tags: Am J Respir Cell Mol Biol Source Type: research