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Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.
Abstract Vascular cell adhesion molecule 1 (VCAM1) is a member of the Immunoglobulin superfamily and encodes a cell surface sialoglycoprotein expressed in cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion, facilitates the downstream signaling, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Accumulating evidence has demonstrated that VCAM1 exerts an anti-apoptotic effect in several tumor tissues such as ovarian cancer and breast cancer. Intracerebral hemorrhage (ICH) is the second most common subtype of stroke with high mo...
Source: Neurochemical Research - April 14, 2015 Category: Neuroscience Authors: Zhang D, Yuan D, Shen J, Yan Y, Gong C, Gu J, Xue H, Qian Y, Zhang W, He X, Yao L, Ji Y, Shen A Tags: Neurochem Res Source Type: research