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Production and Characterization of Monoclonal Antibody against Vit v1: A Grape Allergen Belonging to Lipid Transfer Protein Family.
Abstract Allergy to non-specific lipidtransfer protein (nsLTP), the major allergen of grape (Vit v1), is considered as one of the most common fruit allergies in Iran. Therefore, a specific monoclonal antibody (mAb) can be used for the characterization and assessment of. Accordingly, this study aimed to generate and characterize a mAb against Vit v1 with a diagnostic purpose. To this end, Vit v1 allergen (9 kDa) was extracted using a modified Bjorksten extraction method. Natural Vit v1-immunized mouse splenocytes were fused with SP2/0Ag-14 myeloma cells for generating hybridoma cells. Specific antibody-secreting Hy...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 15, 2020 Category: Allergy & Immunology Authors: Hosseinpour M, Mashayekhi K, Falak R, Jamalzehi S, Mohammadian Haftcheshmeh S, Mousavi MJ, Soleimani A, Koushki K, Sankian M, Soukhtanloo M Tags: Iran J Allergy Asthma Immunol Source Type: research