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Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL
Conclusions: This study showed that USPIO-enhanced brain MRI can be useful in the diagnosis of CNS inflammatory disorders and lymphoma, and is also useful for patients with renal compromise at risk of nephrogenic systemic fibrosis who are unable to receive GBCA.
Source: Neurology - July 15, 2013 Category: Neurology Authors: Farrell, B. T., Hamilton, B. E., Dosa, E., Rimely, E., Nasseri, M., Gahramanov, S., Lacy, C. A., Frenkel, E. P., Doolittle, N. D., Jacobs, P. M., Neuwelt, E. A. Tags: MRI, All Cerebrovascular disease/Stroke, All Oncology ARTICLE Source Type: research

Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation
Conclusion: The identification of one or several nonenhancing space-occupying lesions, especially in elderly patients presenting with cognitive impairment, should raise suspicion for the pseudotumoral presentation of CAA-I and lead to T2*-GRE sequences. Perfusion MRI and MRS appear to be useful techniques for the differential diagnosis of this entity.
Source: Neurology - March 7, 2016 Category: Neurology Authors: Ronsin, S., Deiana, G., Geraldo, A. F., Durand-Dubief, F., Thomas-Maisonneuve, L., Formaglio, M., Desestret, V., Meyronet, D., Nighoghossian, N., Berthezene, Y., Honnorat, J., Ducray, F. Tags: MRI, MRS, Other cerebrovascular disease/ Stroke, Primary brain tumor ARTICLE Source Type: research

Fool Me Once: An Uncommon Presentation of PE
​BY FREDDIE IRIZARRY-DELGADO; VAROON KAKAIYA; & AHMED RAZIUDDIN, MDAn 86-year-old African-American woman was brought to the ED by her daughter after two days of nutritional neglect, abdominal pain, and altered mental status. Her daughter said her mother felt lightheaded, appeared dehydrated, and vomited nonbilious watery fluid once. The patient had a history of diabetes mellitus type 2, DVT/PE, dementia, and early signs of parkinsonism.Her vital signs were remarkable only for tachypnea (24 bpm). Her troponin I was markedly elevated at 1.7 ng/mL. A D-dimer was ordered because of her history of unprovoked DVT/PE, and i...
Source: The Case Files - November 27, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research