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Cancer: Lymphoma
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Total 590 results found since Jan 2013.
The Construction and Characterization of 1F5 Chimeric Anti-CD20 Monoclonal Antibodies: An Efficient Splicing by Overlap Extension-polymerase Chain Reaction Technique
In this study, the conversion of 1F5 mAb from mouse IgG2a to human-mouse chimeric IgG1 was achieved and the chimeric antibody was partially characterized. We constructed the 1F5 chimeric mouse-human anti-CD20 antibody genes using an efficient Splicing by overlap extension-polymerase chain reaction (SOE-PCR) technique and cloned the chimeric heavy and light genes in pBudCE4.1mammalian expression vector, followed by purification of the expressed chimeric 1F5 mAbs using affinity chromatography. Our investigation also included the biological properties of purified chimeric antibodies. The generated 1F5 chimeric mAbs mediate co...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 27, 2021 Category: Allergy & Immunology Authors: Fatemeh Khademi Pantea Mohammadi Ali Mostafaei Source Type: research
Korean Adolescent Patient with Manifestations of Lymphocyte Variant Hypereosinophilic Syndrome and Episodic Angioedema with Eosinophilia, Treated with Reslizumab
Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):215-218. doi: 10.18502/ijaai.v21i2.9229.ABSTRACTA four-year-old female patient visited the pediatric hematologic clinic due to periodic generalized edema and eosinophilia. Laboratory assessment showed an eosinophil count of 40.02×109/L (73.6% of white blood cells). A bone marrow aspirate smear film showed no signs of malignant cells but had hypercellular marrow particles with eosinophilia (45% of all nucleated cells) and 52% of eosinophils were immature. Other laboratory tests showed an increased IgM level of 827 mg/dL, and lymphocyte phenotyping by flow cytometry revealed ...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 1, 2022 Category: Allergy & Immunology Authors: Jie Hee Jue Ye Jee Shim Sunggyun Park Do-Hoon Kim Hye Ra Jung Source Type: research
Scales of Magt1 Gene: Novel Mutations, Different Presentations
Iran J Allergy Asthma Immunol. 2022 Feb 6;21(1):92-97. doi: 10.18502/ijaai.v21i1.8622.ABSTRACTLoss-of-function mutations in magnesium transporter 1 (MAGT1) gene cause X-linked magnesium deficiency with Epstein-Barr virus (EBV) infection and neoplasm (X-MEN), a disease with quite diverse clinical and immunological consequences. The phenotypic characteristics of the initially described patients included CD4+ T cell lymphopenia, immune deficiency, EBV viremia, and EBV-related lymphoproliferative disease. To date, a total of 25 patients have been reported. The spectrum of the MAGT1 defect ranges from other viral infections (HS...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 7, 2022 Category: Allergy & Immunology Authors: Sule Haskologlu Kubra Baskin Caner Aytekin Candan Islamoglu Serdar Ceylaner Figen Dogu Nurdan Tacyildiz Emel Unal Aydan Ikinciogullari Source Type: research
Korean Adolescent Patient with Manifestations of Lymphocyte Variant Hypereosinophilic Syndrome and Episodic Angioedema with Eosinophilia, Treated with Reslizumab
Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):215-218. doi: 10.18502/ijaai.v21i2.9229.ABSTRACTA four-year-old female patient visited the pediatric hematologic clinic due to periodic generalized edema and eosinophilia. Laboratory assessment showed an eosinophil count of 40.02×109/L (73.6% of white blood cells). A bone marrow aspirate smear film showed no signs of malignant cells but had hypercellular marrow particles with eosinophilia (45% of all nucleated cells) and 52% of eosinophils were immature. Other laboratory tests showed an increased IgM level of 827 mg/dL, and lymphocyte phenotyping by flow cytometry revealed ...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 1, 2022 Category: Allergy & Immunology Authors: Jie Hee Jue Ye Jee Shim Sunggyun Park Do-Hoon Kim Hye Ra Jung Source Type: research
