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Atorvastatin inhibits cholesterol-induced caspase-3 cleavage through down-regulation of p38 and up-regulation of Bcl-2 in the rat carotid artery.
CONCLUSIONS: The resultant data suggest that the anti-apoptotic effect of AV could be partially mediated by the pro-inflammatory protein p38 MAPK and the anti-apoptotic protein Bcl-2 in the rat carotid artery. Atorvastatin can therefore be considered a target drug in the prevention or development of atherosclerotic events. PMID: 28498386 [PubMed - as supplied by publisher]
Source: Cardiovascular Journal of Africa - May 5, 2017 Category: Cardiology Authors: Bayatmakoo R, Rashtchizadeh N, Yaghmaei P, Farhoudi M, Karimi P Tags: Cardiovasc J Afr Source Type: research