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CD8+ T-cells Co-expressing PD-1 and TIGIT Are Highly Frequent in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2021 Dec 8;20(6):751-763. doi: 10.18502/ijaai.v20i6.8027.ABSTRACTThe role of immune checkpoint receptors in T-cell exhaustion has been demonstrated in several cancers. We investigated the co-expression of TIGIT/PD-1 and LAG-3/PD-1 cells in patients with chronic lymphocytic leukemia (CLL). The frequencies of TIGIT+PD-1+CD8+and LAG-3+PD-1+CD8+cells and relative mRNA expression of LSECtin and CD155 were examined in PBMCs from 33 CLL patients and 20 controls. The percentage of TIGIT+PD-1+CD8+cells was significantly higher in CLL patients than in control subjects, with the preference in advanced s...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 18, 2021 Category: Allergy & Immunology Authors: Reza Hajiasghar-Sharbaf Hossein Asgarian-Omran Reza Valadan Hadi Hossein-Nattaj Ramin Shekarriz Ehsan Zaboli Ghasem Janbabaei Mohsen Tehrani Source Type: research
