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Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of < em > GABARAPL1 < /em > in acute myeloid leukemia cells
Int J Oncol. 2023 Jul;63(1):87. doi: 10.3892/ijo.2023.5535. Epub 2023 Jun 16.ABSTRACTMacroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial for autophagosome biogenesis. Although the regulatory machinery of autophagy in the cytoplasm has been widely studied, its transcriptional and epigenetic regulatory mechanisms still req...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Ying Song Jiaqi Zhang Haihua Wang Haiying Wang Yong Liu Zhenbo Hu Source Type: research

Epigenetic silencing of ZCCHC10 by the lncRNA SNHG1 promotes progression and venetoclax resistance of acute myeloid leukemia
In conclusion, ZCCHC10 expression is suppressed by SNHG1‑induced DNA methylation in AML. Downregulation of ZCCHC10 decreases p53 activation, promotes cell proliferation and survival, and thereby accelerates AML progression and the acquisition of venetoclax resistance. The present study identified a SNHG1/ZCCHC10/p53 signaling axis in AML that may be a therapeutic target in this malignancy.PMID:37052262 | DOI:10.3892/ijo.2023.5512
Source: International Journal of Oncology - April 13, 2023 Category: Cancer & Oncology Authors: Hao Zhou Qing Zhang Wei Huang Chunping He Chang Zhou Jianlin Zhou Yichong Ning Source Type: research

Liproxstatin ‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells
Int J Oncol. 2022 Oct;61(4):119. doi: 10.3892/ijo.2022.5409. Epub 2022 Aug 25.ABSTRACTLeukemia is a fatal hematopoietic disorder with a poor prognosis. Drug resistance is inevitable after the long‑term use of chemotherapeutic agents. Liproxstatin‑1, commonly known as a ferroptosis inhibitor, has never been reported to have anticancer effects. In the present study, the antileukemic role of liproxstatin‑1 in K562 leukemia cells was investigated. Liproxstatin‑1 inhibited K562 cell proliferation in a dose‑ and time‑dependent manner. RNA sequencing revealed several pathways that were affected by liproxstatin‑1, su...
Source: International Journal of Oncology - August 25, 2022 Category: Cancer & Oncology Authors: Hai-Qun Dong Shi-Jing Liang Yu-Ling Xu Yi Dai Na Sun Dong-Hong Deng Peng Cheng Source Type: research

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