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Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid Receptor
Biomed Res Int. 2022 Jul 6;2022:6865472. doi: 10.1155/2022/6865472. eCollection 2022.ABSTRACTBetamethasone is an important glucocorticoids (GCs), frequently used to cure allergies (such as asthma and angioedema), Crohn's disease, skin diseases (such as dermatitis and psoriasis), systemic lupus erythematosus, rheumatic disorders, and leukemia. Present investigation deals to find potential agonist of glucocorticoid receptors after biotransformation of betamethasone dipropionate (1) and to carry out the molecular docking and ADME analyses. Biotransformation of 1 was carried out with Launaea capitata (dandy) roots and Musa acu...
Source: Biomed Res - July 22, 2022 Category: Research Authors: Sana Rashid Shazia Anjum Aqeel Ahmad Raziya Nadeem Maqsood Ahmed Syed Adnan Ali Shah Muhammad Abdullah Komal Zia Zaheer Ul-Haq Source Type: research

Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation
In this study, we propose a new allergy model system for studying potential allergen epitopes using nanoallergens, liposomes modified to effectively display IgE binding epitopes/haptens. By utilizing the covalently conjugated lipid tails on two hapten molecules (dinitrophenol and dansyl), hapten molecules were successfully incorporated into liposomes with high precision to form nanoallergens. Nanoallergens, with precisely controlled high-particle valency, can trigger degranulation with much greater sensitivity than commonly used bovine serum albumin conjugates. In rat basophil leukemia cell experiments, nanoallergens with ...
Source: Experimental Biology and Medicine - May 12, 2016 Category: Research Authors: Deak, P. E., Vrabel, M. R., Pizzuti, V. J., Kiziltepe, T., Bilgicer, B. Tags: Original Research Source Type: research