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Cancer: Leukemia

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Total 693 results found since Jan 2013.

Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells
This study aimed to evaluate the effect of LIF on natural killer group 2 member D (NKG2D) receptors' expression and presentation on natural killer (NK) cells. For this purpose, peripheral blood mononuclear cells taken from 4 young male healthy blood donors were isolated and the effect of LIF (25 ng/mL) after 12, 24, and 48 hours of incubation, on NKG2D receptors expression and presentation was investigated using flow cytometry and real-time-polymerase chain reaction (PCR). All of the steps of the experiment were performed in duplicate. After periods of 12, 24, and 48 hours, LIF reduced both the expression and presentation ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Zahra Abdoli Mohammad-Ali Assarehzadegan Mohammad Hassan Pipelzadeh Sara Iranparast Nader Dashti Gerdabi Mehdi Parsanahad Ali Khodadadi Source Type: research

Plasma Levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA-125a-5p as Potential Diagnostic Biomarkers for Rheumatoid Arthris
This study aims to evaluate the expression of microRNA (miR)-146a-5p, miR-24-3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. This study was performed on 50 RA patients and 50 healthy controls. Five microliters of blood were taken from each patient/control. Plasma RNA was extracted using the Trisol solution. cDNAs were synthesized; using moloney murine leukemia virus (MMLV) and deoxynucleoside triphosphate (dNTP). Real-time PCR was performed using SYBR green kit. The mean expres...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Fatemeh Safari Elia Damavandi Abdol-Rahman Rostamian Shafieh Movassaghi Zeinab Imani-Saber Mojtaba Saffari Majid Kabuli Mohsen Ghadami Source Type: research