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Cancer: Leukemia
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Total 693 results found since Jan 2013.
CD8+ T-cells Co-expressing PD-1 and TIGIT Are Highly Frequent in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2021 Dec 8;20(6):751-763. doi: 10.18502/ijaai.v20i6.8027.ABSTRACTThe role of immune checkpoint receptors in T-cell exhaustion has been demonstrated in several cancers. We investigated the co-expression of TIGIT/PD-1 and LAG-3/PD-1 cells in patients with chronic lymphocytic leukemia (CLL). The frequencies of TIGIT+PD-1+CD8+and LAG-3+PD-1+CD8+cells and relative mRNA expression of LSECtin and CD155 were examined in PBMCs from 33 CLL patients and 20 controls. The percentage of TIGIT+PD-1+CD8+cells was significantly higher in CLL patients than in control subjects, with the preference in advanced s...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 18, 2021 Category: Allergy & Immunology Authors: Reza Hajiasghar-Sharbaf Hossein Asgarian-Omran Reza Valadan Hadi Hossein-Nattaj Ramin Shekarriz Ehsan Zaboli Ghasem Janbabaei Mohsen Tehrani Source Type: research
Korean Adolescent Patient with Manifestations of Lymphocyte Variant Hypereosinophilic Syndrome and Episodic Angioedema with Eosinophilia, Treated with Reslizumab
Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):215-218. doi: 10.18502/ijaai.v21i2.9229.ABSTRACTA four-year-old female patient visited the pediatric hematologic clinic due to periodic generalized edema and eosinophilia. Laboratory assessment showed an eosinophil count of 40.02×109/L (73.6% of white blood cells). A bone marrow aspirate smear film showed no signs of malignant cells but had hypercellular marrow particles with eosinophilia (45% of all nucleated cells) and 52% of eosinophils were immature. Other laboratory tests showed an increased IgM level of 827 mg/dL, and lymphocyte phenotyping by flow cytometry revealed ...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 1, 2022 Category: Allergy & Immunology Authors: Jie Hee Jue Ye Jee Shim Sunggyun Park Do-Hoon Kim Hye Ra Jung Source Type: research
The Effects of PI3K/Akt/mTOR Signaling Pathway Inhibitors on the Expression of Immune Checkpoint Ligands in Acute Myeloid Leukemia Cell Line
Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):178-188. doi: 10.18502/ijaai.v21i2.9225.ABSTRACTUp-regulation of immune checkpoint ligands is considered as one of the most important immune escape mechanisms in acute myeloid leukemia (AML). Herein, we investigate a relationship between the inhibition of PI3K/Akt/mTOR signaling pathways and the regulation of immune checkpoint ligands in AML cells. The HL-60 cell line was treated with idelalisib as PI3K inhibitor, MK-2206 as Akt inhibitor, and everolimus as mTOR inhibitor either in a single or combined format. Cell viability and apoptosis were evaluated using MTT and flow cy...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 1, 2022 Category: Allergy & Immunology Authors: Saeid Taghiloo Saeid Norozi Hossein Asgarian-Omran Source Type: research
