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Specialty: Biomedical Science
Cancer: Colorectal Cancer
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Total 581 results found since Jan 2013.
Construction of a novel cancer-associated fibroblast-related signature to predict clinical outcome and immune response in colon adenocarcinoma
Aging (Albany NY). 2023 Sep 16;15. doi: 10.18632/aging.205032. Online ahead of print.ABSTRACTThe interaction between the tumour and the surrounding microenvironment determines the malignant biological behaviour of the tumour. Cancer-associated fibroblasts (CAFs) coordinate crosstalk between cancer cells in the tumour immune microenvironment (TIME) and are extensively involved in tumour malignant behaviours, such as immune evasion, invasion and drug resistance. Here, we performed differential and prognostic analyses of genes associated with CAFs and constructed CAF-related signatures (CAFRs) to predict clinical outcomes in ...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Lei Zheng Jiale Zhang Yingquan Ye Zhangpeng Shi Yi Huang Mengmeng Zhang Zhongxuan Gui Ping Li Huanlong Qin Weijie Sun Mei Zhang Source Type: research
The lncRNA MIR99AHG directs alternative splicing of < em > SMARCA1 < /em > by PTBP1 to enable invadopodia formation in colorectal cancer cells
Sci Signal. 2023 Sep 19;16(803):eadh4210. doi: 10.1126/scisignal.adh4210. Epub 2023 Sep 19.ABSTRACTAlternative splicing regulates gene expression and functional diversity and is often dysregulated in human cancers. Here, we discovered that the long noncoding RNA (lncRNA) MIR99AHG regulated alternative splicing to alter the activity of a chromatin remodeler and promote metastatic behaviors in colorectal cancer (CRC). MIR99AHG was abundant in invasive CRC cells and metastatic tumors from patients and promoted motility and invasion in cultured CRC cells. MIR99AHG bound to and stabilized the RNA splicing factor PTBP1, and this...
Source: Science Signaling - September 19, 2023 Category: Biomedical Science Authors: Danxiu Li Xin Wang Hui Miao Hao Liu Maogui Pang Hao Guo Minghui Ge Sarah E Glass Stephan Emmrich Songtao Ji Yun Zhou Xiaoni Ye Huajie Mao Jing Wang Qi Liu Taewan Kim Jan-Henning Klusmann Cunxi Li Zhenxiong Liu Haifeng Jin Yongzhan Nie Kaichun Wu Daiming F Source Type: research
< em > KIF18A < /em > improves migration and invasion colorectal cancer (CRC) cells through inhibiting < em > PTEN < /em > signaling
CONCLUSION: In conclusion, KIF18A can further the activation of PI3K/Akt signaling pathway by means of inhibiting PTEN transcription. Therefore, it is inferred that that KIF18A is a therapeutic target for CRC.PMID:37708299 | DOI:10.18632/aging.205027
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Yuan Liu Ming Sun Bin Zhang Wenyan Zhao Source Type: research
IFN γ synergies with cold atmospheric plasma in triggering colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis
Aging (Albany NY). 2023 Sep 4;15. doi: 10.18632/aging.204985. Online ahead of print.ABSTRACTColorectal cancer accounts for the second most common cancer-related lethality. Intestinal stem cells are responsible for enteric homeostasis maintenance that, once being transformed, become colorectal cancer stem cells. Arresting cancer stemness represents an innovative strategy for colorectal cancer management. Using intestinal stem cell organoids as the primary model, we screened common inflammatory cytokines to identify key players targeting cancer stemness. We also explored the downstream signaling that drives the functionaliti...
Source: Aging - September 6, 2023 Category: Biomedical Science Authors: Xinyu Lv Fu-le He Yilin Dai Xiaofeng Dai Source Type: research
m < sup > 6 < /sup > A methyltransferase METTL16 mediates immune evasion of colorectal cancer cells via epigenetically regulating PD-L1 expression
CONCLUSIONS: Our work identified the METTL16/PD-L1/PD-1 regulatory axis in CRC development and immune evasion, which represented a promising target for CRC treatment.PMID:37647025 | DOI:10.18632/aging.204980
Source: Aging - August 30, 2023 Category: Biomedical Science Authors: Ailei Wang Yingjie Sun Xince Wang Zhaofei Yan Dongsheng Wang Li Zeng Qingge Lu Source Type: research
The novel angiogenesis regulator circFAM169A promotes the metastasis of colorectal cancer through the angiopoietin-2 signaling axis
Aging (Albany NY). 2023 Aug 23;15. doi: 10.18632/aging.204974. Online ahead of print.ABSTRACTBACKGROUND: Angiogenesis plays an important role in the metastasis of cancers. However, the mechanisms whereby circular RNAs (circRNAs) regulate angiogenesis and affect cancer metastasis are still unclear.METHODS: We used gene set variation and Spearman's correlation analyses to identify novel angiogenesis-related circRNAs, including circFAM169A. The Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to assess the potential biological function of circFAM169A. A quantitative reverse transcription-PCR (qRT-PCR) analy...
Source: Aging - August 24, 2023 Category: Biomedical Science Authors: Zhiwei Wu Fan Zhang Shaobin Huang Ming Luo Kai Yang Source Type: research
