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Use of Circulating Cell-Free DNA to Guide Precision Medicine in Patients with Colorectal Cancer
Annu Rev Med. 2021 Jan 27;72:399-413. doi: 10.1146/annurev-med-070119-120448.ABSTRACTPatient-specific biomarkers form the foundation of precision medicine strategies. To realize the promise of precision medicine in patients with colorectal cancer (CRC), access to cost-effective, convenient, and safe assays is critical. Improvements in diagnostic technology have enabled ultrasensitive and specific assays to identify cell-free DNA (cfDNA) from a routine blood draw. Clinicians are already employing these minimally invasive assays to identify drivers of therapeutic resistance and measure genomic heterogeneity, particularly whe...
Source: Annual Review of Medicine - January 27, 2021 Category: General Medicine Authors: Van K Morris John H Strickler Source Type: research
