Filtered By:
Source: Cell Biology International
Cancer: Colorectal Cancer
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 16 results found since Jan 2013.
A novel therapeutic drug for colon cancer: EpCAM scFv-truncated protamine (tp)-siRNA.
Abstract
Colon cancer is a type of malignant tumor that causes considerable mortality worldwide. Epithelial cellular adhesion molecule (EpCAM), a tumor-associated antigen of colon tumors, is a target for colon cancer therapy. EpCAM-specific monoclonal antibodies (mAbs) have been applied in human colon cancer since the 1990s; however, the therapeutic effects are limited. EpCAM activates nuclear signaling pathways by releasing its intracellular domain (EpICD). The released EpICD stimulates the Wnt/β-catenin signaling pathway, which is also strongly associated with tumorigenesis. EpCAM is also a target gene of the W...
Source: Cell Biology International - April 10, 2013 Category: Cytology Authors: Hao H, Zhen Y, Wang Z, Chen F, Xie X Tags: Cell Biol Int Source Type: research
