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Source: GEO: Gene Expression Omnibus
Cancer: Breast Cancer
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Total 79 results found since Jan 2013.
GSE240039 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein ATAC
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of ...
Source: GEO: Gene Expression Omnibus - August 10, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE236275 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of PVRL4 are elev...
Source: GEO: Gene Expression Omnibus - July 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE227774 Differential gene expression profile analysis of parental, Cas9-p15 control, and MELK knockout cells
Contributor : Chandra BartholomeuszSeries Type : Expression profiling by arrayOrganism : Homo sapiensTriple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSCs), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase of the Snf1/AMPK kinase family, is known to promote CSC maintenance and malignant transformation. Our study showed that MELK knockdown using siRNA or MELK inhibition using the MELK inhibitor MELK-In-17 significantly reduced invasiveness, reversed epithelial-to-mesenchymal t...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE225459 A heterodimer of α and β hemoglobin chains functions as an innate anticancer agent
Contributors : Maharrish Chelladurai ; Dan Xu ; Sivan Izraely ; Roman Bengaiev ; Orit Sagi-Assif ; Weirong Yuan ; Metsada Pasmanik Chor ; Dave S Hoon ; Wuyuan Lu ; Isaac P WitzSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensMetastatic (as well as tumor) microenvironments contain both cancer-promoting as well as cancer restraining factors. The balance between these opposing forces determines the fate of cancer cells that disseminate to secondary organ sites. In search for microenvironmental drivers or inhibitors of metastasis, we identified, in a previous study, the beta subunit of hemoglobin (HBB) as...
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research
GSE145729 Estrogen-induced CircRNA, CircPGR, Functions as a CeRNA to Promote Estrogen Receptor-positive Breast Cancer Progression by Regulating Cell Cycle-related Genes
Contributors : Wen Liu ; Lei Wang ; Guosheng Hu ; Yi C LiuSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensEstrogen and estrogen receptor (ER)-mediated gene transcriptional events have been well known to be involved in ER-positive breast carcinogenesis. Meanwhile, circular RNAs (circRNAs) are emerging as a new family of functional non-coding RNAs (ncRNAs) with implications in a variety of pathological processes, such as cancer. However, the estrogen-regulated circRNA program and the function of such program remain uncharacterized...
Source: GEO: Gene Expression Omnibus - February 13, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE209693 Effect of AKTIP depletion in breast cancer cells
Contributor : Lydia W CheungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCopy number loss of AKTIP gene is frequently observed in breast cancer particularly luminal breast cancer. To determine the alterations in transcriptome upon AKTIP loss in luminal breast cancer cell line MCF7 and triple negative breast cancer cell line SKBR3, RNAseq of cells transfected with AKTIP siRNA was performed.
Source: GEO: Gene Expression Omnibus - August 19, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE207714 Identification of recurrent chromosome breaks underlying structural rearrangements in mammary cancer cell lines Break-seq
We present evidence from RNA-seq data that select genes, including SHCBP1, ORC6 and MYLK3, which are immediately downstream from the 16q pericentromere show heightened expression in MCF-7 cell line compared to the control. Data published by The Cancer Genome Atlas showed that all three genes have increased expression in breast tumor samples. We suggest that these genes are potential oncogenes for breast cancer progression. The search for tumor suppressor loss that accompanies the 16q loss ought to be augmented by the identification of potential oncogenes that gained expression during chromosomal rearrangements.
Source: GEO: Gene Expression Omnibus - July 12, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE207697 Identification of recurrent chromosome breaks underlying structural rearrangements in mammary cancer cell lines DNA-seq
We present evidence from RNA-seq data that select genes, including SHCBP1, ORC6 and MYLK3, which are immediately downstream from the 16q pericentromere show heightened expression in MCF-7 cell line compared to the control. Data published by The Cancer Genome Atlas showed that all three genes have increased expression in breast tumor samples. We suggest that these genes are potential oncogenes for breast cancer progression. The search for tumor suppressor loss that accompanies the 16q loss ought to be augmented by the identification of potential oncogenes that gained expression during chromosomal rearrangements.
Source: GEO: Gene Expression Omnibus - July 12, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE207696 Identification of recurrent chromosome breaks underlying structural rearrangements in mammary cancer cell lines RNA-seq
We present evidence from RNA-seq data that select genes, including SHCBP1, ORC6 and MYLK3, which are immediately downstream from the 16q pericentromere show heightened expression in MCF-7 cell line compared to the control. Data published by The Cancer Genome Atlas showed that all three genes have increased expression in breast tumor samples. We suggest that these genes are potential oncogenes for breast cancer progression. The search for tumor suppressor loss that accompanies the 16q loss ought to be augmented by the identification of potential oncogenes that gained expression during chromosomal rearrangements.
Source: GEO: Gene Expression Omnibus - July 12, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE133012 Measuring the transcriptomic response to targeting kinases correlated with estrogen receptor activity in Breast Cancer
Contributors : Simona Schindler ; Amy Cullen ; Helen V Cook ; Florian Markowetz ; Andrew N HoldingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe undertook a phosophotranscriptomic network analysis of published patient tumour RNA-seq and phosphoproteomic data to identify kinases that correltated with Estrogen Receptor activity in Breast Cancer. The most sucessful canidates were selected for targeting by siRNA and the effects monitored by RNA-seq.
Source: GEO: Gene Expression Omnibus - June 18, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE115475 Effects of siRNA-mediated knockdownof RUNX1 expression in breast cancer cells
Contributors : Chin-Yo Lin ; Nicholes CandelariaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrevious studies have identified an interaction between RUNX1 and estrogen receptor alpha and its potential role in estrogen signaling in breast cancer. To determine the transcriptomic actions of RUNX1, we knocked down its expression by using siRNAs, both in the absence and presence of estradiol (E2).
Source: GEO: Gene Expression Omnibus - June 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE163553 Gene expression data from human breast cancer MCF-7 cells treated with siRNAs targeting SCFD2
Contributors : Toshihiko Takeiwa ; Kazuhiro Ikeda ; Kuniko Horie-Inoue ; Satoshi InoueSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo examine the role of SCFD2 in breast cancer, MCF-7 cells were treated with siRNAs targeting SCFD2 (siSCFD2) or control siRNA (siControl). SCFD2 silencing represses expressions of anti-apoptotic genes which are positively associated with shorter relapse-free survival in ER-positive breast cancer patients. These results reveal the clinical and functional significance of SCFD2 and its targets in hormone-dependent breast cancer. SCFD2 may be applied to the cancer management a...
Source: GEO: Gene Expression Omnibus - May 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE192548 Transcriptome analysis of MCF10A-M2 cells upon the depletion of OVOL1 or OVOL2
Contributors : Chuannan Fan ; Cedrick Agaser ; Hailiang Mei ; Peter ten DijkeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOVOL1 protein was shown to be downregulated in breast cancer patient samples and was inversely correlated with the epithelial-to-mesenchymal transition (EMT) signature. To better dissect the downstream target genes and elucidate the signaling pathways altered by OVOL1, we deplete OVOL1 by the specific siRNA in MCF10A-M2 cells. To set as a control, OVOL2 was knockdown by the specific siRNA in the same cell line. The total RNA was collected and sent for RNA sequen...
Source: GEO: Gene Expression Omnibus - December 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE190541 BRD4 regulates N6-methyladenosine modification of ESPL1 mRNA via interaction with RNA demethylase ALKBH5 to modulate breast cancer progression
Contributors : Hongsheng Wang ; Haisheng Zhang ; Linlin Lu ; Jiexin LiSeries Type : OtherOrganism : Homo sapiensN6-methyladenosine (m6A) is important for RNA metabolism including stability and translation of messenger RNA (mRNA). Recent studies indicate that m6A-methylated RNA can modulate dynamic chromatin accessibility and gene transcription, while the potential link of chromatin to mRNA m6A remains largely unknown. We found that targeted inhibition of bromodomain-containing protein 4 (BRD4) by siRNA or a small compound inhibitor (JQ1) significantly decreases mRNA m6A levels and suppresses the malignancy of breast cancer...
Source: GEO: Gene Expression Omnibus - December 11, 2021 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE189718 The role of ZNF32 in modulating transcriptoion of MCF-7
Contributors : Di Gong ; Ping LinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensZinc finger protein 32 (ZNF32), is regarded as a transcription factor that regulates gene transcription. But the function of ZNF32 in breast cancer metastasis remains unknown. Here, the MCF-7 was transfected with the pENTER-ZNF32 or empty vector to search the target genes with ChIP-seq.
Source: GEO: Gene Expression Omnibus - November 30, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
