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Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53
This article is protected by copyright. All rights reserved.
Source: Cancer Science - October 1, 2017 Category: Cancer & Oncology Authors: Ryota Koyama, Miyuki Tamura, Takafumi Nakagaki, Tomoko Ohashi, Masashi Idogawa, Hiromu Suzuki, Takashi Tokino, Yasushi Sasaki Tags: Original Article Source Type: research

Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis
It is well known that comedo necrosis is closely associated with an aggressive phenotype of ductal carcinoma in situ (DCIS) of human breast, but its molecular mechanisms remain largely unclear. Therefore, in this study, we first examined the gene expression profile of comedo DCIS based on microarray data and identified CYC1 as a gene associated with comedo necrosis. Cytochrome c1 (CYC1) is a subunit of complex III in the mitochondrial oxidative phosphorylation that is involved in energy production. However, the significance of CYC1 has not yet been examined in DCIS. We therefore immunolocalized CYC1 in 47 DCIS cases. CYC1 ...
Source: Cancer Science - May 19, 2017 Category: Cancer & Oncology Authors: Mayuko Chishiki, Kiyoshi Takagi, Ai Sato, Yasuhiro Miki, Yuta Yamamoto, Akiko Ebata, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Takashi Suzuki Tags: Original Article Source Type: research

Insulin ‐like growth factor‐1 signaling is responsible for cathepsin G‐induced aggregation of breast cancer MCF‐7 cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - April 1, 2017 Category: Cancer & Oncology Authors: Riyo Morimoto ‐Kamata, Satoru Yui Tags: Original Article Source Type: research

Inhibiting Autophagy Increases Epirubicin's Cytotoxicity in Breast Cancer Cells
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Source: Cancer Science - August 24, 2016 Category: Cancer & Oncology Authors: Wei Guo, Yu Wang, Zhu Wang, Yan ‐Ping Wang, Hong Zheng Tags: Original Article Source Type: research

Nek2 siRNA therapy using a portal venous port –catheter system for liver metastasis in pancreatic cancer
In this study, the overexpression of Nek2 was identified in pancreatic cancer cell lines. Nek2 siRNA inhibited tumor growth in a subcutaneous xenograft mouse model of pancreatic cancer, prolonged the survival time in an intraperitoneal xenograft mouse model and efficiently prevented the progression of liver metastasis using a portal venous port–catheter system. Taken together, Nek2 is an effective therapeutic target in pancreatic cancer. An adequate delivery system is considered important in treating advanced pancreatic cancer, such as peritoneal dissemination and liver metastasis. Further investigations are required on ...
Source: Cancer Science - August 11, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research

Nek2 siRNA therapy using a portal venous port ‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 17, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research

Nek2 siRNA therapy using a portal venous port‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 31, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research

CRKL oncogene is downregulated by p53 through miR‐200s
Tumor suppressive miRNAs that target oncogenes are frequently downregulated in cancers, and this downregulation leads to oncogene pathway activation. Thus, tumor suppressive miRNAs and their target oncogenes have been proposed as useful targets in cancer treatment. miR‐200 family downregulation has been reported in cancer progression and metastasis. The miR‐200 family consists of two gene clusters, miR‐200b/200a/429 and miR‐200c/141, which are located on human chromosomes 1 and 12, respectively. Here, we identified that p53 response elements are located around both clusters of the miR‐200 family and confirmed tha...
Source: Cancer Science - July 14, 2015 Category: Cancer & Oncology Authors: Miyuki Tamura, Yasushi Sasaki, Kenta Kobashi, Kousuke Takeda, Takafumi Nakagaki, Masashi Idogawa, Takashi Tokino Tags: Original Article Source Type: research

The CRKL oncogene is downregulated by p53 through miR‐200s
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 1, 2015 Category: Cancer & Oncology Authors: Miyuki Tamura, Yasushi Sasaki, Kenta Kobashi, Kousuke Takeda, Takafumi Nakagaki, Masashi Idogawa, Takashi Tokino Tags: Original Article Source Type: research

Expression of BAF57 in ovarian cancer cells and drug sensitivity
In this study, we investigated BAF57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil. BAF57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with BAF57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of BAF57 using specific siRNA increased cell cycle arrest at G1 phase and the sensitivities to these anticancer agents. cDNA microarray analysis of A2780 cells transfected with BAF57 siRNA showe...
Source: Cancer Science - February 25, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

BAF57 expression of ovarian cancer cells and drug sensitivity
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 22, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

Heregulin Induces Resistance to Lapatinib‐mediated Growth Inhibition of HER2‐Amplified Cancer Cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 24, 2013 Category: Cancer & Oncology Authors: Yuji Sato, Masakazu Yashiro, Nobuyuki Takakura Tags: Original Article Source Type: research