• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The purine receptor P2X7R regulates the release of pro-inflammatory cytokines in human craniopharyngioma
In conclusion, the results suggest that P2X7R may promote IL-6, IL-8 and MCP-1 production and secretion and contribute to the invasion and adhesion of CPs to the surrounding tissue.
Source: Endocrine-Related Cancer - May 15, 2017 Category: Endocrinology Authors: Nie, J., Huang, G.-l., Deng, S.-Z., Bao, Y., Liu, Y.-W., Feng, Z.-P., Wang, C.-H., Chen, M., Qi, S.-T., Pan, J. Tags: Research Source Type: research

Drug priming enhances radiosensitivity of adamantinomatous craniopharyngioma via downregulation of survivin.
CONCLUSIONS These results indicate an impact of EGFR signaling on radioresistance in ACP. Inhibition of EGFR activity by means of TKI treatment acts as a radiosensitizer on ACP tumor cells, leading to increased cell death. Additionally, the results emphasize the antiapoptotic and pro-proliferative role of survivin in ACP biology and its regulation by EGFR signaling. The suppression of survivin by treatment with TKI and combined radiotherapy represents a new promising treatment strategy that will be further assessed in in vivo models of ACP. PMID: 27903123 [PubMed - in process]
Source: Neurosurgical Focus - November 30, 2016 Category: Neurosurgery Authors: Stache C, Bils C, Fahlbusch R, Flitsch J, Buchfelder M, Stefanits H, Czech T, Gaipl U, Frey B, Buslei R, Hölsken A Tags: Neurosurg Focus Source Type: research