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DKK3 Overexpression Increases Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.
Authors: Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Terada K, Itadani M, Okada N, Hassan NMM, Nagatsuka H, Ikeda T, Nohno T, Fujita S Abstract DKK3, a member of dickkopf WNT signaling pathway inhibitor family, is believed to be a tumor suppressor, because of itsreduced expression in cancer cells. However, our previous studies have revealed that DKK3 expression is predominantly observed in head and neck, and oral squamous cell carcinoma (HNSCC/OSCC). Interestingly, HNSCC/OSCC patients with DKK3 expression showed high metastasis rate and poorer survival, and siRNA-mediated knockdown of DKK3 in HNSCC-derived can...
Source: Oncology Research - May 6, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
CONCLUSIONS: LAMC2 interacts with autophagy to regulate OSCC metastasis, invasion, and proliferation via the PI3K/AKT/mTOR pathway. LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration, invasion, and proliferation.PMID:37415741 | PMC:PMC10319602 | DOI:10.32604/or.2023.029064
Source: Oncology Research - July 7, 2023 Category: Cancer & Oncology Authors: Fayu Shan Lanlan Liang Chong Feng Hongbao Xu Zirou Wang Weili Liu Lingling Pu Zhaoli Chen Gang Chen Xinxing Wang Source Type: research

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