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Cell-penetrating albumin enhances the sublingual delivery of antigens through macropinocytosis
Int J Biol Macromol. 2022 Sep 17:S0141-8130(22)02063-3. doi: 10.1016/j.ijbiomac.2022.09.132. Online ahead of print.ABSTRACTInnovations in oral immunotherapy have greatly advanced the therapeutic control of allergies. However, these therapeutic effects suffer from the fact that the amount of antigen delivered to antigen-presenting cells is limited given the formulations that are currently available. We recently designed a cell-penetrating albumin and found that this modified albumin enters cells via the induction of macropinocytosis. Herein, we report on a novel system for delivering antigens based on cell-penetrating album...
Source: International Journal of Biological Macromolecules - September 20, 2022 Category: Biochemistry Authors: Hitoshi Maeda Shota Ichimizu Hiroshi Watanabe Keisuke Hamasaki Mayuko Chikamatsu Ryota Murata Nao Yumoto Takahiro Seki Hiroshi Katsuki Masaki Otagiri Toru Maruyama Source Type: research