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Suppression of StarD7 promotes endoplasmic reticulum stress and induces ROS production.
Abstract StarD7 is an intracellular lipid transport protein identified as up-regulated in the choriocarcinoma JEG-3 cell line. StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown causes a reduction in phospholipid synthesis. Since inhibition of PC synthesis may lead to endoplasmic reticulum (ER) stress we hypothesized that StarD7 may be involved in maintaining cell homeostasis. Here, we examined the effect of StarD7 silencing on ER stress response and on the levels of reactive oxygen species (ROS) in the human hepatoma cell line HepG2. StarD7 knockdown induced alte...
Source: Free Radical Biology and Medicine - August 19, 2016 Category: Biology Authors: Flores-Martín J, Reyna L, Ridano ME, Panzetta-Dutari GM, Genti-Raimondi S Tags: Free Radic Biol Med Source Type: research

The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells.
In conclusion, benzbromarone increases mitochondrial O2•- accumulation and activates the NRF2 signaling pathway in HepG2 cells, thereby strengthening the cytosolic and mitochondrial antioxidative defense. Impaired antioxidative defense may represent a risk factor for benzbromarone-induced hepatotoxicity. PMID: 32198009 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 16, 2020 Category: Biology Authors: Roos NJ, Duthaler U, Bouitbir J, Krähenbühl S Tags: Free Radic Biol Med Source Type: research