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Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
In this study, we have demonstrated that delivery of OVA+IL-33 to the lungs of mice induced an innate inflammatory response that exhibited sex-dependent differences in magnitude and regulation. Compared to males, female mice produced larger amounts of type 2 cytokines and chemokines and had substantially more activated eosinophils and AAM in the lung; each of these responses was significantly lower in female mice lacking STAT6. On the contrary, male mice displayed less inflammation overall, and in some instances, no apparent role for STAT6 was observed. BALF levels of inflammatory mediators and eosinophils were very lo...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research