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Afatinib maintenance therapy following post-operative radiochemotherapy in head and neck squamous cell carcinoma: Results from the phase III randomised double-blind placebo-controlled study BIB2992ORL (GORTEC 2010-02)
CONCLUSION: Maintenance therapy with afatinib compared with placebo following post-operative RCT in patients with HNSCC did not significantly improve 2y-DFS and should not be recommended in this setting outside clinical trials.CLINICALTRIALS: gov identifier NCT01427478.PMID:36434888 | DOI:10.1016/j.ejca.2022.10.023
Source: Cancer Control - November 26, 2022 Category: Cancer & Oncology Authors: S éverine Racadot Isabelle Thennevet Yaelle Ouldbey Marie-Christine Kaminsky Mathieu Bosset Laurent Martin Yungan Tao Christian Sire Dominique de Raucourt Marc Alfonsi Emmanuelle Malaurie Jean-Marc Tourani Pierre Fournel Elodie Vauleon Anouchka Modesto F Source Type: research

Total laryngectomy for laryngeal cancer 150 years after its first description: A boon more than a calamity: A STROBE analysis
CONCLUSIONS: The 20th century witnessed an incredible turn-around. Total laryngectomy, with limited indications, has transformed the etiology of deaths and no longer leaves patients "in a state of abject misery" as Morell Mackenzie put it in 1888.PMID:36210325 | DOI:10.1016/j.anorl.2022.09.001
Source: Cancer Control - October 9, 2022 Category: Cancer & Oncology Authors: O Laccourreye D Garcia A Mudry Source Type: research

Head and neck cancer and asbestos exposure
CONCLUSIONS: This large-scale study suggests a relationship between asbestos exposure and head and neck cancers, after exclusion of laryngeal cancers, regardless of whether associated pleural plaques were present.PMID:35393288 | DOI:10.1136/oemed-2021-108047
Source: Clinics in Occupational and Environmental Medicine - April 8, 2022 Category: Occupational Health Authors: B énédicte Clin Celine Gramond Isabelle Thaon Patrick Brochard Fleur Delva Soizick Chammings Antoine Gislard Fran çois Laurent Christophe Paris Aude Lacourt Jean-Claude Pairon Source Type: research

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