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LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
CONCLUSIONS: LAMC2 interacts with autophagy to regulate OSCC metastasis, invasion, and proliferation via the PI3K/AKT/mTOR pathway. LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration, invasion, and proliferation.PMID:37415741 | PMC:PMC10319602 | DOI:10.32604/or.2023.029064
Source: Oncology Research - July 7, 2023 Category: Cancer & Oncology Authors: Fayu Shan Lanlan Liang Chong Feng Hongbao Xu Zirou Wang Weili Liu Lingling Pu Zhaoli Chen Gang Chen Xinxing Wang Source Type: research

EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF- β signals.
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-β signals. Oncol Res. 2020 Mar 05;: Authors: Huang Y, Zhu Q, Lu L, Sun S, Hao F, Zhang J, Liu Z, Miao Y, Jiao X, Chen D Abstract Anaplastic thyroid carcinoma (ATC) are resistant to standard therapies and has no effective treatment. Eukaryotic translation initiation factor 5A2 (EIF5A2) has shown to be upregulated inmany malignant tumors and proposed to be a critical gene involved in tumor metastasis. In thisstudy, we aim to investigate the expression status of EIF5A2 in human ATC tissues, an...
Source: Oncology Research - March 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Targeted Silencing of Kim-1 Inhibits the Growth of Clear Cell Renal Carcinoma Cell Line 786-0 In Vitro and In Vivo.
Conclusion, knockdown of Kim-1 inhibits the growth of 786-0 cells in vitro and in vivo, investing Kim-1 can be used as a potential target for clear cell renal carcinoma therapy. PMID: 29295730 [PubMed - as supplied by publisher]
Source: Oncology Research - January 5, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-136 inhibits malignant progression of hepatocellular carcinoma cells by targeting cyclooxygenase 2.
In conclusion, miR-136 was vital in the regulation of HCC cell proliferation and metastasis by targeting COX2. Thus, our findings provided novel evidence that miR-136 might be recommended as a potential target for the diagnosis and treatment of HCC patients. PMID: 29295728 [PubMed - as supplied by publisher]
Source: Oncology Research - January 5, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration.
Authors: Zhang Q, Su R, Shan C, Gao C, Wu P Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here, we identified that NCAPG(non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset. We found that knockdow...
Source: Oncology Research - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

DKK3 Overexpression Increases Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.
Authors: Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Terada K, Itadani M, Okada N, Hassan NMM, Nagatsuka H, Ikeda T, Nohno T, Fujita S Abstract DKK3, a member of dickkopf WNT signaling pathway inhibitor family, is believed to be a tumor suppressor, because of itsreduced expression in cancer cells. However, our previous studies have revealed that DKK3 expression is predominantly observed in head and neck, and oral squamous cell carcinoma (HNSCC/OSCC). Interestingly, HNSCC/OSCC patients with DKK3 expression showed high metastasis rate and poorer survival, and siRNA-mediated knockdown of DKK3 in HNSCC-derived can...
Source: Oncology Research - May 6, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Regulation of Acetate Utilization By Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC).
Authors: Jeon J, Lee M, Whang S, Kim JW, Cho A, Yun M Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal18F-Fluorodeoxyglucose (FDG) and 11C-acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells; in this study, we evaluated the mechanism and roles of 11C-acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of 11C-acetate uptake in HCC cell lines...
Source: Oncology Research - April 9, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

G-Protein Signaling Protein-17 (RGS17) is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.
Authors: Li L, Luo HS Abstract Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma in the very early stage. Herein, we studied the role of regulators of G-protein signaling (RGS) family protein RGS17 in colorectal carcinoma growth and metastasis. We found that RGS17 was upregulated in both clinical colorectal carcinoma tissues and cultured colorectal carcinoma cells. Knockdown of RGS17 by specific siRNA decreased, whereas overexpression of RGS17 with expression pl...
Source: Oncology Research - March 27, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

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