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Source: Cell Biology International
Cancer: Carcinoma

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Total 29 results found since Jan 2013.

SiRNA-targeted carboxypeptidase D inhibits hepatocellular carcinoma growth.
Abstract Carboxypeptidase D (CPD), a membrane-bound metallocarboxypeptidase that functions as a docking receptor for duck hepatitis B virus, is frequently overexpressed in human cancers. We have explored its expression pattern, clinical significance, and biological function of CPD in hepatocellular carcinoma (HCC). CPD expression was markedly elevated in HCCs relative to adjacent non-tumor liver tissues, as determined by quantitative real-time polymerase chain reaction and Western blot analysis. Immunohistochemistry showed that 164 of 400 (41%) HCCs had high expression of CPD. CPD overexpression was significantly ...
Source: Cell Biology International - April 16, 2013 Category: Cytology Authors: Jin T, Fu J, Feng XJ, Wang SM, Huang X, Zhu MH, Zhang SH Tags: Cell Biol Int Source Type: research

NF-κBP65 promotes invasion and metastasis of oesophageal squamous cell cancer by regulating matrix metalloproteinase-9 and epithelial-to-mesenchymal transition.
Abstract NF-κB has been recognized as one of the factors responsible for the development of cancer; however, the mechanism by which high expression of NF-κB contributes to the progression of human oesophageal squamous cell cancer (ESCC) is not fully understood. In our investigations, NF-κBP65 was overexpressed in human ESCC tissues, especially in ESCC tissues with deep invasion and lymph node metastasis. Suppression of NF-κBP65 by siRNA decreased the invasion and proliferation ability of EC9706 cells in vitro. Furthermore, siRNA-mediated NF-κBP65 knock-down could lead to the downregulation of MMP-9, a metasta...
Source: Cell Biology International - March 15, 2013 Category: Cytology Authors: Wang F, He W, Wang PF, Fan Q Tags: Cell Biol Int Source Type: research

RNA interference targeting CD147 inhibits the invasion of human cervical squamous carcinoma cells by downregulating MMP-9.
Abstract Cervical squamous carcinoma is a highly invasive tumour that has a great capacity to metastasise. Extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin superfamily, is a widely distributed cell surface glycoprotein. It is highly expressed on malignant tumour cell surfaces, including human cervical squamous carcinoma. It also plays a critical role in the invasive and metastatic activity of malignant cells by stimulating the expression of matrix metalloproteinases (MMPs). The anti-invasive effect of small interfering RNA (siRNA) against CD147 on human cervical squ...
Source: Cell Biology International - March 28, 2013 Category: Cytology Authors: Fan X, Wu W, Shi H, Han J Tags: Cell Biol Int Source Type: research

Calpains are required for invasive and metastatic potentials of human HCC cells.
Abstract Calpains are a conserved family of calcium-dependent cysteine proteinases involved in various cellular functions. Two ubiquitous isoforms, µ- and m-calpain, are key members of the calpain family that play essential roles in regulating cell migration and invasion. However, it remains unclear whether they are involved in the progression of hepatocellular carcinoma (HCC). Here, we investigated the functions of µ- and m-calpain in the invasive and metastatic processes of human hepatoma cells. Our results indicated that the expression levels of calpains were elevated in HCC cells compared with those in norma...
Source: Cell Biology International - June 7, 2013 Category: Cytology Authors: Chen B, Tang J, Guo YS, Li Y, Chen ZN, Jiang JL Tags: Cell Biol Int Source Type: research

Knockdown of tumor protein D52-like 2 induces cell growth inhibition and apoptosis in oral squamous cell carcinoma.
Abstract Tumor protein D52-like 2 (TPD52L2) and its family members form homo- and heteromeric complexes essential for cell proliferation in multiple human cancers. TPD52L2 is involved in cell migration and attachment in oral squamous cell carcinoma (OSCC). To confirm the role of TPD52L2 in OSCC, we employed the lentivirusdelivered small interfering RNA (siRNA) technique to knock down TPD52L2 expression in 2 OSCC cell lines, CAL27 and KB. Knockdown of TPD52L2 by RNA interference markedly suppressed cell proliferation and colony formation. Cell cycle analysis showed that depletion of TPD52L2 led to CAL27 cells arres...
Source: Cell Biology International - September 27, 2014 Category: Cytology Authors: He Y, Chen F, Cai Y, Chen S Tags: Cell Biol Int Source Type: research

NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6 induced JAK2/STAT3 pathway activation.
This article is protected by copyright. All rights reserved. PMID: 32584509 [PubMed - as supplied by publisher]
Source: Cell Biology International - June 24, 2020 Category: Cytology Authors: Kang JH, Li MJ, Luan PP, Jiang DK, Chen YW, Xu X, Yu Q, Xu YW, Su Q, Peng WH, Jian WX Tags: Cell Biol Int Source Type: research

PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway.
In conclusion, PSPH could induce autophagy, promote proliferation and invasion, and inhibit apoptosis in HCC cell via the AMPK/mTOR/ULK1 signaling pathway. This article is protected by copyright. All rights reserved. PMID: 33079432 [PubMed - as supplied by publisher]
Source: Cell Biology International - October 20, 2020 Category: Cytology Authors: Zhang J, Wang E, Zhang L, Zhou B Tags: Cell Biol Int Source Type: research

miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro
This study was designed to investigate the relationship between miR-4443 and TRIM14 on metastasis and energy metabolism in PTC and the underlying mechanisms. To this end, human PTC cells (SW1736 and MZ-CRC-1) were transfected with a miR-4443 mimic or miR-4443 inhibitor + siRNA-TRIM14, and then dual luciferase assay, Transwell, Seahorse, and Western blot were performed to assess the function of miR-4443 and the underlying mechanism. We found that ectopic expression of miR-4443 inhibited PTC cell migration, invasion, ATP production, and aerobic glycolysis, while inhibition of miR-4443 had the opposite effect. miR-4443 direct...
Source: Cell Biology International - May 29, 2021 Category: Cytology Authors: Xiao-Ming Zuo Hai-Wen Sun Hong Fang Yun Wu Qun Shi Yi-Fan Yu Source Type: research