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Systemic glucocorticoid use and early-onset basal cell carcinoma
Immunosuppressive medications are common in the management of numerous conditions, such as organ transplantation, allergies, and respiratory disorders [1]. In some patients with conditions, such as organ transplantation, that require long-term high-dose immunosuppression, immunosuppressives increase risk for squamous cell carcinoma of the skin (SCC; 60- to 250-fold increase), and to a lesser extent for basal cell carcinoma (BCC; 10-fold increase) [2–10]. An increased risk of nonmelanoma skin cancer (NMSC) has also been associated with immunosuppressives among rheumatoid arthritis and inflammatory bowel disease patients [11–13].
Source: Annals of Epidemiology - May 22, 2014 Category: Epidemiology Authors: Jose Ramon Troche, Leah M. Ferrucci, Brenda Cartmel, David J. Leffell, Allen E. Bale, Susan T. Mayne Tags: Rapid Report Source Type: research