Filtered By:
Source: Cancer Science
Cancer: Carcinoma
This page shows you your search results in order of date.
Order by Relevance | Date
Total 24 results found since Jan 2013.
Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis
It is well known that comedo necrosis is closely associated with an aggressive phenotype of ductal carcinoma in situ (DCIS) of human breast, but its molecular mechanisms remain largely unclear. Therefore, in this study, we first examined the gene expression profile of comedo DCIS based on microarray data and identified CYC1 as a gene associated with comedo necrosis. Cytochrome c1 (CYC1) is a subunit of complex III in the mitochondrial oxidative phosphorylation that is involved in energy production. However, the significance of CYC1 has not yet been examined in DCIS. We therefore immunolocalized CYC1 in 47 DCIS cases. CYC1 ...
Source: Cancer Science - May 19, 2017 Category: Cancer & Oncology Authors: Mayuko Chishiki, Kiyoshi Takagi, Ai Sato, Yasuhiro Miki, Yuta Yamamoto, Akiko Ebata, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Takashi Suzuki Tags: Original Article Source Type: research
p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1 ‐NF‐κB pathway in human ovarian cancer cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 12, 2017 Category: Cancer & Oncology Authors: Xiao ‐Yu Yan, Yu Zhang, Juan‐Juan Zhang, Li‐Chao Zhang, Ya‐Nan Liu, Yao Wu, Ya‐Nan Xue, Sheng‐Yao Lu, Jing Su, Lian‐Kun Sun Tags: Original Article Source Type: research
Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma
Emerging evidence has indicated that deregulation of long non‐coding RNAs (lncRNAs) can contribute to the progression and metastasis of human cancer, including hepatocellular carcinoma (HCC). However, the roles of most lncRNAs in HCC remain largely unknown. Here we found a long noncoding RNA termed SchLAH (seven chromosome locus associated with HCC; also called BC035072) was generally downregulated in HCC. Low expression of SchLAH was significantly correlated with shorter overall survival of HCC patients. In vitro and in vivo assays indicated that overexpression of SchLAH inhibited the migration and lung metastasis of H...
Source: Cancer Science - April 17, 2017 Category: Cancer & Oncology Authors: Zhouhong Ge, Zhuoan Cheng, Xinrong Yang, Xisong Huo, Ning Wang, Hui Wang, Cun Wang, Dishui Gu, Fangyu Zhao, Ming Yao, Jia Fan, Wenxin Qin Tags: Original Article Source Type: research
CYC1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - March 1, 2017 Category: Cancer & Oncology Authors: Mayuko Chishiki, Kiyoshi Takagi, Ai Sato, Yasuhiro Miki, Yuta Yamamoto, Akiko Ebata, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Takashi Suzuki Tags: Original Article Source Type: research
EphB3 ‐targeted regulation of miR‐149 in the migration and invasion of human colonic carcinoma HCT116 and SW620 cells
In conclusion,the important role of miR‐149 in colorectal cancer progression suggesting that miR‐149 may serve as a therapeutic target for colorectal cancer treatment.
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 10, 2017 Category: Cancer & Oncology Authors: Guodong Zhang, Xiaozhu Liu, Yinfeng Li, Yan wang, Huankun Liang, Kangyan Li, Laiqing Li, Cuicui Chen, Wenqiao Sun, Shoulei Ren, Pengfei Zhu, Licheng Zhang Tags: Original Article Source Type: research
The long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with FUS
This article is protected by copyright. All rights reserved.
Source: Cancer Science - December 31, 2016 Category: Cancer & Oncology Authors: Zhouhong Ge, Zhuoan Cheng, Xinrong Yang, Xisong Huo, Ning Wang, Hui Wang, Cun Wang, Dishui Gu, Fangyu Zhao, Ming Yao, Jia Fan, Wenxin Qin Tags: Original Article Source Type: research
Impact of Sulfatase ‐2 on cancer progression and prognosis in patients with renal cell carcinoma
Heparan sulfate‐specific endosulfatase‐2 (SULF‐2) can modulate the signaling of heparan sulfate proteoglycan‐binding proteins. The involvement of SULF‐2 in cancer growth varies by cancer type. The roles of SULF‐2 expression in the progression and prognosis of renal cell carcinomas (RCC) have not yet been fully clarified. In the present study, the expression levels of SULF‐2 mRNA and protein in 49 clinical RCC samples were determined by RT‐PCR and immunostaining. The existence of RCC with higher SULF‐2 expression and lower SULF‐2 expression compared to the adjacent normal kidney tissues was suggested. Hi...
Source: Cancer Science - November 28, 2016 Category: Cancer & Oncology Authors: Shin Kumagai, Kei Ishibashi, Masao Kataoka, Toshiki Oguro, Yuichirou Kiko, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima Tags: Original Article Source Type: research
The impact of Sulfatase ‐2 on cancer progression and prognosis in patients with renal cell carcinoma
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 1, 2016 Category: Cancer & Oncology Authors: Shin Kumagai, Kei Ishibashi, Masao Kataoka, Toshiki Oguro, Yuichirou Kiko, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima Tags: Original Article Source Type: research
Role of galectin ‐1 in urinary bladder urothelial carcinoma cell invasion through c‐Jun N‐terminal protein kinase pathway
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 30, 2016 Category: Cancer & Oncology Authors: Kun ‐Hung Shen, Chien‐Feng Li, Lan‐Hsiang Chien, Cheng‐Hao Huang, Chia‐Cheng Su, Alex C Liao, Ting‐Feng Wu Tags: Original Article Source Type: research
Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis
In this study, we found that MMP13 was overexpressed in NPC cells and exosomes purified from conditioned medium (CM) as well as NPC patients’ plasma. Transwell analysis revealed that MMP13‐containing exosomes facilitated the metastasis of NPC cells. Furthermore, siRNA inhibited the effect of MMP13‐containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP13‐containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions.
This work proved that MMP13‐containning exos...
Source: Cancer Science - October 13, 2015 Category: Cancer & Oncology Authors: Yiwen You, Ying Shan, Jing Chen, Huijun Yue, Bo You, Si Shi, Xingyu Li, Xiaolei Cao Tags: Original Article Source Type: research
MMP13‐containing exosomes promote nasopharyngeal carcinoma metastasis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 12, 2015 Category: Cancer & Oncology Authors: You Yiwen, Ying Shan, Jing Chen, Huijun Yue, You Bo, Si Shi, Xingyu Li, Xiaolei Cao Tags: Original Article Source Type: research
Histone deacetylase 3 expression correlates with vasculogenic mimicry through the phosphoinositide3‐kinase / ERK–MMP–laminin5γ2 signaling pathway
In this study, we subjected glioma specimens to immunohistochemical and histochemical double‐staining methods and found that VM and HDAC3 expression were related to the pathological grade of gliomas. The presence of VM correlated with HDAC3 expression in glioma tissues. The formation of tubular structures, as determined by the tube formation assay to evaluate VM, was impaired in U87MG cells when transfected by siRNA or treated with an HDAC3 inhibitor. Importantly, the expression of VM‐related molecules such as MMP‐2/14 and laminin5γ2 was also affected when HDAC3 expression was altered. Furthermore, U87MG cells were ...
Source: Cancer Science - June 18, 2015 Category: Cancer & Oncology Authors: Xiao Liu, Ji‐Hui Wang, Shun Li, Lin‐Lin Li, Min Huang, Yong‐Hong Zhang, Yang Liu, Yuan‐Tao Yang, Rui Ding, Yi‐Quan Ke Tags: Original Article Source Type: research
HDAC3 expression correlates with vasculogenic mimicry via the PI3K/ERK‐MMPs‐Ln5γ2 signaling pathway
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 2, 2015 Category: Cancer & Oncology Authors: Xiao Liu, Ji‐Hui Wang, Shun Li, Lin‐Lin Li, Min Huang, Yong‐Hong Zhang, Yang Liu, Yuan‐Tao Yang, Rui Ding, Yi‐Quan Ke Tags: Original Article Source Type: research
Activation of AMP‐activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib
In this study, we investigated the effects of combined treatment using sorafenib and retinoids including all‐trans retinoic acid (ATRA), NIK‐333, and Am80 on HCC cells. Cell viability assays in six HCC cell lines, HepG2, PLC/PRF/5, HuH6, HLE, HLF, and Hep3B, revealed that 5 and 10 μM ATRA, concentrations that do not exert cytotoxic effects, enhanced the cytotoxicity of sorafenib, being much more effective than NIK‐333 and Am80. We found that ATRA induced AMP‐activated protein kinase activation, which was followed by reduced intracellular ATP level. Gene expression analysis revealed that ATRA decreased the express...
Source: Cancer Science - March 9, 2015 Category: Cancer & Oncology Authors: Naoki Ishijima, Keita Kanki, Hiroki Shimizu, Goshi Shiota Tags: Original Article Source Type: research
Expression of BAF57 in ovarian cancer cells and drug sensitivity
In this study, we investigated BAF57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil. BAF57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with BAF57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of BAF57 using specific siRNA increased cell cycle arrest at G1 phase and the sensitivities to these anticancer agents. cDNA microarray analysis of A2780 cells transfected with BAF57 siRNA showe...
Source: Cancer Science - February 25, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research
