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Condition: Emphysema
Cancer: Epithelial Cancer
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LSC - 2017 - The role of the epigenetic regulator HMGN5 in COPD resulting from chronic lung injury
COPD, characterized by chronic bronchitis, small airway remodeling and emphysema, is one of the leading causes of chronic morbidity and mortality worldwide. Chronic lung injury, commonly caused by cigarette smoking (CS), is a major factor in its development. A role for epigenetics in this underlying pathology is emerging. We previously detected spontaneous emphysema in HMGN5-/-mice. HMGN5 binds to the nucleosomal core particle of chromatin, competing with histone H1, altering chromatin structure and affecting cellular transcription, differentiation and repair. Indeed, increased expression of HMGN5 has been observed in lung...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Gunes, G., Conlon, T., Sarker, R., Burgstaller, G., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., Furusawa, T., Bustin, M., Eickelberg, O., Önder Yildirim, A., Dorer, J. Tags: Molecular Pathology and Functional Genomics Source Type: research
