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Total 194 results found since Jan 2013.

Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research

Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection
Physiol Rev. 2022 Mar 28. doi: 10.1152/physrev.00017.2021. Online ahead of print.ABSTRACTAging is the single largest risk factor for many debilitating conditions, including heart diseases, stroke, cancer, diabetes, and neurodegenerative disorders. While far from understood in its full complexity, it is scientifically well-established that aging is influenced by genetic and environmental factors, and can be modulated by various interventions. One of aging's early hallmarks are aberrations in transcriptional networks, controlling for example metabolic homeostasis or the response to stress. Evidence in different model organis...
Source: Physiological Reviews - March 28, 2022 Category: Physiology Authors: Fabian Fischer Giovanna Grigolon Christoph Benner Michael Ristow Source Type: research

Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research

Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection
Physiol Rev. 2022 Mar 28. doi: 10.1152/physrev.00017.2021. Online ahead of print.ABSTRACTAging is the single largest risk factor for many debilitating conditions, including heart diseases, stroke, cancer, diabetes, and neurodegenerative disorders. While far from understood in its full complexity, it is scientifically well-established that aging is influenced by genetic and environmental factors, and can be modulated by various interventions. One of aging's early hallmarks are aberrations in transcriptional networks, controlling for example metabolic homeostasis or the response to stress. Evidence in different model organis...
Source: Physiological Reviews - March 28, 2022 Category: Physiology Authors: Fabian Fischer Giovanna Grigolon Christoph Benner Michael Ristow Source Type: research

Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research

Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection
Physiol Rev. 2022 Mar 28. doi: 10.1152/physrev.00017.2021. Online ahead of print.ABSTRACTAging is the single largest risk factor for many debilitating conditions, including heart diseases, stroke, cancer, diabetes, and neurodegenerative disorders. While far from understood in its full complexity, it is scientifically well-established that aging is influenced by genetic and environmental factors, and can be modulated by various interventions. One of aging's early hallmarks are aberrations in transcriptional networks, controlling for example metabolic homeostasis or the response to stress. Evidence in different model organis...
Source: Physiological Reviews - March 28, 2022 Category: Physiology Authors: Fabian Fischer Giovanna Grigolon Christoph Benner Michael Ristow Source Type: research