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Source: Cancers
Cancer: Cancer
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Total 602 results found since Jan 2013.
Cancers, Vol. 15, Pages 4686: The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review
ldaiturriaga
Medulloblastoma (MB) is the most common malignant brain tumor in childhood. Although recent multi-omic studies have led to advances in MB classification, there is still room for improvement with regard to treatment response and survival. Therefore, identification of new and less invasive biomarkers is needed to refine the diagnostic process and to develop more personalized treatment strategies. In this context, non-coding RNAs (ncRNAs) could be useful biomarkers for MB. In this article, we reviewed the role of two types of ncRNAs, long non-coding (lncRNAs) and circular RNAs (circRNAs), as biomarkers for th...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Ivan Martinez de Estibariz Anastasija Jakjimovska Unai Illarregi Idoia Martin-Guerrero Angela Guti érrez-Camino Elixabet Lopez-Lopez Nerea Bilbao-Aldaiturriaga Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4680: Health-Related Quality of Life Outcomes in Meningioma Patients Based upon Tumor Location and Treatment Modality: A Systematic Review and Meta-Analysis
S. D’Amico
Patients with meningiomas may have reduced health-related quality of life (HRQoL) due to postoperative neurological deficits, cognitive dysfunction, and psychosocial burden. Although advances in surgery and radiotherapy have improved progression-free survival rates, there is limited evidence regarding treatment outcomes on HRQoL. This review examines HRQoL outcomes based on tumor location and treatment modality. A systematic search in PubMed yielded 28 studies with 3167 patients. The mean age was 54.27 years and most patients were female (70.8%). Approximately 78% of meningiomas were located in the skull ...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Ali San Raphia K. Rahman Praveen Sanmugananthan Michael D. Dub é Nicholas Panico Ogechukwu Ariwodo Vidur Shah Randy S. D ’Amico Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4558: Indirect Treatment Comparison of First-Line CDK4/6-Inhibitors in Post-Menopausal Patients with HR+/HER2 & minus; Metastatic Breast Cancer
Conclusions: Findings from this indirect treatment comparison suggest no significant PFS or OS differences between CDK4/6-inhibitors in post-menopausal patients with HR+/HER- MBC.
Source: Cancers - September 14, 2023 Category: Cancer & Oncology Authors: Joseph J. Zhao Khi Yung Fong Yiong Huak Chan Jeremy Tey Shaheenah Dawood Soo Chin Lee Richard S. Finn Raghav Sundar Joline S. J. Lim Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4539: Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma
In conclusion, the high expression of NRG prognostic signature is associated with poor prognosis in OSCC, and HPRT1 can serve as a novel independent prognostic factor for OSCC.
Source: Cancers - September 13, 2023 Category: Cancer & Oncology Authors: Ke Huang Xiaoting Gu Huimei Xu Hui Li Mingxuan Shi Defang Wei Shiqi Wang Yao Li Bin Liu Yi Li Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4495: Modern Kidney-Sparing Management of Upper Tract Urothelial Carcinoma
Conclusion: KSSs are acceptable approaches for patients with low- and select high-risk UTUCs, which preserve renal function without compromising the oncological outcomes.
Source: Cancers - September 10, 2023 Category: Cancer & Oncology Authors: Alireza Ghoreifi Reza Sari Motlagh Gerhard Fuchs Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4502: Role of Prehabilitation and Rehabilitation on Functional Recovery and Quality of Life in Thyroid Cancer Patients: A Comprehensive Review
Conclusions: This narrative review provides valuable insights into the current prehabilitation and rehabilitation strategies to treat thyroid cancer survivors, addressing physical, psychological, and vocational needs to optimize functional outcomes and enhance their quality of life.
Source: Cancers - September 10, 2023 Category: Cancer & Oncology Authors: Lorenzo Lippi Alessio Turco Stefano Moalli Marco Gallo Claudio Curci Antonio Maconi Alessandro de Sire Marco Invernizzi Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4486: Prognostic Factors in Extremity Soft Tissue Sarcomas Treated with Radiotherapy: Systematic Review of the Literature
The objective of this systematic review is to analyze the available scientific data on prognostic factors concerning the characteristics of the patients, the disease and the treatments performed, as well as their potential complications, on studies with a median follow-up of 5 years at minimum. A search of articles following the “PRISMA method” and using the PubMed search engine was conducted to select the most relevant studies. Twenty-five articles were selected, according to preestablished criteria. This review provides a better understanding of the prognosis and disease outcome of these tumor...
Source: Cancers - September 9, 2023 Category: Cancer & Oncology Authors: Arthur Lebas Clara Le F èvre Waisse Waissi Isabelle Chambrelant David Brinkert Georges No ël Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4470: Systematic Review of the Survival Outcomes of Neoadjuvant Chemotherapy in Women with Malignant Ovarian & mdash;An Germ Cell Tumors
In conclusion, NACT may be considered for the management of MOGCT; however, possible candidates for NACT use and an ideal number of NACT cycles remain unknown. Further studies are warranted to validate the efficacy of NACT in advanced MOGCT patients.
Source: Cancers - September 8, 2023 Category: Cancer & Oncology Authors: Hitomi Sakaguchi-Mukaida Shinya Matsuzaki Yutaka Ueda Satoko Matsuzaki Mamoru Kakuda Misooja Lee Satoki Deguchi Mina Sakata Michihide Maeda Reisa Kakubari Tsuyoshi Hisa Seiji Mabuchi Shoji Kamiura Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4450: Morphea, Eosinophilic Fasciitis and Cancer: A Scoping Review
This study is limited by the type of articles included (case reports, case series and observational studies), and hence, additional research on this important topic is needed.
Source: Cancers - September 7, 2023 Category: Cancer & Oncology Authors: Maxine Joly-Chevrier Alexa G élinas Stephanie Ghazal Sarah Moussa Catherine C. McCuaig Maryam Piram Alexandra Mereniuk Ivan V. Litvinov Mohammed Osman Kevin Pehr Elena Netchiporouk Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4414: Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship
einbolt
Sagar D. Sardesai
Anne M. Noonan
Daniel G. Stover
Mathew A. Cherian
William B. Malarkey
Janice K. Kiecolt-Glaser
About one-in-three breast cancer survivors have lingering cognitive complaints and objective cognitive impairment. Chronic inflammation and intestinal permeability (i.e., leaky gut), two risk factors for cognitive decline, can also fuel depression—another vulnerability for cognitive decline. The current study tested whether depression accompanied by high levels of inflammation or intestinal permeability predicted lower subjective and objective cognitive function in breast ca...
Source: Cancers - September 4, 2023 Category: Cancer & Oncology Authors: Annelise A. Madison Rebecca Andridge Anthony H. Kantaras Megan E. Renna Jeanette M. Bennett Catherine M. Alfano Stephen P. Povoski Doreen M. Agnese Maryam Lustberg Robert Wesolowski William E. Carson Nicole O. Williams Raquel E. Reinbolt Sagar D. Sardesai Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4405: Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide
Maria Paula Curado
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature. CPGs were selected for ...
Source: Cancers - September 3, 2023 Category: Cancer & Oncology Authors: Lady Paola Aristizabal Arboleda Genival Barbosa de Carvalho Alan Roger Santos-Silva Gisele Aparecida Fernandes Jose Guilherme Vartanian David I. Conway Shama Virani Paul Brennan Luiz Paulo Kowalski Maria Paula Curado Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4404: PET/CT and Conventional Imaging for the Assessment of Neuroendocrine Prostate Cancer: A Systematic Review
Conclusion: Published data on the role of PET/CT for the assessment of NEPC are limited. At present, it is still uncertain which tracer performs best, and although [18F]FDG has been evaluated and seems to offer some advantages in availability and clinical staging, other tracers may be more useful to understand tumor biology or identify targets for subsequent radioligand therapy. Further research is therefore desirable. In contrast, data are still limited to draw a final conclusion on the role and the specific characteristics of CI in this rare form of neoplasm, and therefore, more studies are needed in this setting.
Source: Cancers - September 3, 2023 Category: Cancer & Oncology Authors: Francesco Dondi Alessandro Antonelli Nazareno Suardi Andrea Emanuele Guerini Domenico Albano Silvia Lucchini Luca Camoni Giorgio Treglia Francesco Bertagna Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4366: Recruitment and Retention Strategies Used in Dietary Randomized Controlled Interventions with Cancer Survivors: A Systematic Review
Conclusions: Recruitment goals and methods are frequently reported; reporting of retention methods and goals is limited. Efforts are needed to improve reporting of retention methods and rates to inform best practices and enhance the rigor of future dietary intervention trials.
Source: Cancers - September 1, 2023 Category: Cancer & Oncology Authors: Samantha J. Werts Sarah A. Lavelle Tracy E. Crane Cynthia A. Thomson Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4364: Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
nabel Sorolla
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has transformed oncology research in many ways. Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be faced. In this work, we have explained what CRISPR consists of and listed its applications in breast cancer while focusing on TNBC research. These are disease modelling, the search for novel genes involved in tumour progression, sensitivity to drugs and immunotherapy response, tumour fitness, diagnosis, and trea...
Source: Cancers - September 1, 2023 Category: Cancer & Oncology Authors: Mariona Pont Marta Marqu és Maria Alba Sorolla Eva Parisi Izaskun Urdanibia Seraf ín Morales Antonieta Salud Anabel Sorolla Tags: Review Source Type: research
