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Apigenin Mediated Protection of OGD-Evoked Neuron-Like Injury in Differentiated PC12 Cells.
Abstract Ischemic stroke has been confirmed to cause neuronal injury due to its insufficient supply of glucose and oxygen to brain tissue. Previous research has shown that oxidative stress, a result of excessive accumulation of reactive oxygen species (ROS), relates to pathophysiology of ischemic stroke, and causes oxidative damage to biomolecules, eventually leading to programmed cell death. Meanwhile, apigenin has been shown to exhibit antioxidant, anti-inflammatory, anti-cancer properties and neuroprotective action. Hence, this study was to investigate the potential mechanisms underlying the neural protection o...
Source: Neurochemical Research - September 11, 2014 Category: Neuroscience Authors: Guo H, Kong S, Chen W, Dai Z, Lin T, Su J, Li S, Xie Q, Su Z, Xu Y, Lai X Tags: Neurochem Res Source Type: research

Pretreatment by Evodiamine is Neuroprotective in Cerebral Ischemia: Up-Regulated pAkt, pGSK3β, Down-Regulated NF-κB Expression, and Ameliorated BBB Permeability.
Abstract Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Evodiamine (Evo) has been proved to elicit a variety of biological effects through its anti-inflammatory property in the treatment of infectious disease, Alzheimer's disease and hypoxia-induced inflammatory response. Whether this protective effect applies to cerebral ischemic injury, we therefore investigated the potential neuroprotective role of Evo and the underlying mechanisms. Male Institute of Cancer Research (ICR) mice were subjected to permanent middle cerebral artery occlusion (...
Source: Neurochemical Research - June 12, 2014 Category: Neuroscience Authors: Zhao T, Zhang X, Zhao Y, Zhang L, Bai X, Zhang J, Zhao X, Chen L, Wang L, Cui L Tags: Neurochem Res Source Type: research

Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.
Abstract Vascular cell adhesion molecule 1 (VCAM1) is a member of the Immunoglobulin superfamily and encodes a cell surface sialoglycoprotein expressed in cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion, facilitates the downstream signaling, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Accumulating evidence has demonstrated that VCAM1 exerts an anti-apoptotic effect in several tumor tissues such as ovarian cancer and breast cancer. Intracerebral hemorrhage (ICH) is the second most common subtype of stroke with high mo...
Source: Neurochemical Research - April 14, 2015 Category: Neuroscience Authors: Zhang D, Yuan D, Shen J, Yan Y, Gong C, Gu J, Xue H, Qian Y, Zhang W, He X, Yao L, Ji Y, Shen A Tags: Neurochem Res Source Type: research

Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System
Neurochem Res. 2021 Aug 7. doi: 10.1007/s11064-021-03412-z. Online ahead of print.ABSTRACTResveratrol is a phenol compound produced by some plants in response to pathogens, infection, or physical injury. It is well-known that resveratrol has antioxidant and protective roles in damages potentially caused by cancer or other serious disorders. Thus, it is considered as a candidate agent for the prevention and treatment of human diseases. Evidence has confirmed other bioactive impacts of resveratrol, including cardioprotective, anti-tumorigenic, anti-inflammatory, phytoestrogenic, and neuroprotective effects. Ischemia-reperfus...
Source: Neurochemical Research - August 8, 2021 Category: Neuroscience Authors: Alireza Sarkaki Mojtaba Rashidi Mina Ranjbaran Aram Asareh Zadegan Dezfuli Zahra Shabaninejad Ebrahim Behzad Maryam Adelipour Source Type: research