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The anticoagulation dilemma and future treatment avenues in patients with breast cancer and atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia, with a substantial rise in global incidence and prevalence. Ischemic stroke is a frequent complication of AF, since AF perfectly fulfills Virchow's triad of blood stasis, vascular damage and hypercoagulation, making oral anticoagulation (OAC) obligatory for stroke prevention. Direct oral anticoagulants (DOAC), such as dabigatran, which inhibits thrombin, and apixaban, edoxaban and rivaroxaban, which block the activated coagulation factor X (FXa), have some advantages and are largely replacing coumarin-based OAC.
Source: International Journal of Cardiology - September 30, 2020 Category: Cardiology Authors: Anke C. Fender, Dobromir Dobrev Tags: Editorial Source Type: research

Arterial thrombotic events and acute coronary syndromes with cancer drugs: Are growth factors the missed link? What both cardiologist and oncologist should know about novel angiogenesis inhibitors
Abstract: We aimed to revise the increasingly accruing data about the association between anti-tyrosinkinase, “targeted” cancer drugs and the development of arterial thrombotic events or acute coronary syndromes. Further insights into the involved pathophysiologic mechanisms, and into the clinical implications are overviewed.Antiangiogenesis has become a mainstream of cancer therapy, leading to development of a specific class of drugs. Besides, a “wider” angiogenesis network made up of several growth factors, can be recognized as target of a higher number of compounds. Their widespread use has been progressively fa...
Source: International Journal of Cardiology - February 14, 2013 Category: Cardiology Authors: Elena Conti, Adriana Romiti, Maria Beatrice Musumeci, Jasmine Passerini, Luigi Zezza, Vittoria Mastromarino, Chiara D'Antonio, Paolo Marchetti, Francesco Paneni, Camillo Autore, Massimo Volpe Tags: Reviews Source Type: research

Heme iron intake and acute myocardial infarction: A prospective study of men
Conclusions: Findings from this prospective study indicate that a high heme iron intake, particularly with simultaneous low intake of minerals that can decrease iron absorption, may increase the risk of fatal AMI.
Source: International Journal of Cardiology - January 22, 2014 Category: Cardiology Authors: Joanna Kaluza, Susanna C. Larsson, Niclas Håkansson, Alicja Wolk Tags: Original Articles Source Type: research

The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population: Results of the REACTION study
Conclusion: Both general and abdominal obesity were associated with elevated prevalent cardiovascular diseases and 10-year CHD risk, regardless of the presence or absence of insulin resistance.
Source: International Journal of Cardiology - February 6, 2014 Category: Cardiology Authors: Jieli Lu, Yufang Bi, Tiange Wang, Weiqing Wang, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Qin Wan, Shengli Wu, Guijun Qin, Tao Yang, Li Yan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan Gao, Qing Su, Tags: Original Articles Source Type: research

Association of soy food intake with risk and biomarkers of coronary heart disease in Chinese men
Soy food intake has been associated with a reduced risk of coronary heart disease (CHD) in women, but its association with CHD in men is unclear . Several studies have found sex differences in the associations of soy intake with metabolic syndrome, endothelial function, and other cardiovascular risk factors . In the Shanghai Men's Health Study , we investigated the association between soy food intake and incident CHD among 55,474 Chinese men (40–74years) who were free of CHD, stroke, and cancer at baseline (2002–2006). We also examined the associations of soy intake with multiple CHD biomarkers in a subsample of 3885 m...
Source: International Journal of Cardiology - January 21, 2014 Category: Cardiology Authors: Danxia Yu, Xianglan Zhang, Yong-Bing Xiang, Gong Yang, Honglan Li, Sergio Fazio, MacRae Linton, Qiuyin Cai, Wei Zheng, Yu-Tang Gao, Xiao-Ou Shu Tags: Online Letters to the Editor Source Type: research

Efficacy of ezetimibe: A real effect?
We do not agree with the methods and the conclusions of the systematic review of Savarese et al. [1]. Their meta-analysis of seven randomized controlled trials tests the safety and the efficacy of ezetimibe (E), added to a statin, in comparison indifferently versus placebo or active treatment and shows a favorable effect of E on risks of major non-fatal endpoints (myocardial infarction RR: 0.865, 95% CI: 0.801–0.934; stroke RR: 0.840, 95% CI: 0.744–0.949), with a neutral effect on mortality outcomes (all-cause death RR: 1.003, 95% CI: 0.954–1.055; CV death RR: 0.958, 95% CI: 0.879–1.044) and new cancer risk (RR: 1....
Source: International Journal of Cardiology - February 24, 2016 Category: Cardiology Authors: Alberto Donzelli, Alessandro Battaggia Tags: Correspondence Source Type: research

Direct oral anticoagulants in the prevention of stroke in breast cancer patients with atrial fibrillation during adjuvant endocrine therapy: A cohort study
Atrial fibrillation (AF) is a frequent comorbidity in malignant patients. Anticancer therapies complicate anticoagulant strategy. We evaluated the safety and efficacy of long-term use of direct oral anticoagulants (DOACs) in breast cancer women.
Source: International Journal of Cardiology - September 11, 2020 Category: Cardiology Authors: Renata Pacholczak-Madej, Stanis ława Bazan-Socha, Lech Zaręba, Anetta Undas, Jerzy Dropiński Source Type: research