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A cationic amino acid polymer nanocarrier synthesized in supercritical CO < sub > 2 < /sub > for co-delivery of drug and gene to cervical cancer cells
Colloids Surf B Biointerfaces. 2022 May 18;216:112584. doi: 10.1016/j.colsurfb.2022.112584. Online ahead of print.ABSTRACTThe present study was undertaken to investigate the ability of a drug curcumin-loaded polymer to inhibit the growth of cervical cancer cells by enhancing the anti-cancer efficiency of curcumin. We synthesized poly(methacryloyl beta-alanine) (PMBA) as a nanocarrier by radical polymerization in supercritical CO2. The results showed that the curcumin encapsulated and folic acid (FA)-treated PMBA (Poly@Cur-FA) for 24 h activated the reactive oxygen species-mediated programmed cell death machinery in HeLa ce...
Source: Colloids and Surfaces - May 26, 2022 Category: Biotechnology Authors: K V Kavya Stella Vargheese Shruti Shukla Imran Khan Debasish Kumar Dey Vivek K Bajpai Kavitha Thangavelu Raju Vivek R T Rajendra Kumar Young-Kyu Han Yun Suk Huh Yuvaraj Haldorai Source Type: research

Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells.
Abstract Co-delivery of therapeutic agents and small interfering RNA (siRNA) can be achieved by a suitable nanovehicle. In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a polyplex was formed by grafting Bcl-2 siRNA onto the surface amine groups to produce PAMAM-Cur/Bcl-2 siRNA nanoparticles (NPs). The synthesized polyplex NPs had a particle size of ∼180 nm, and high Cur loading content of ∼82 wt%. Moreover, the PAMAM-Cur/Bcl-2 siRNA NPs showed more effective cellular uptake, and higher inhibition of tumor cell proliferat...
Source: Colloids and Surfaces - December 26, 2019 Category: Biotechnology Authors: Ghaffari M, Dehghan G, Baradaran B, Zarebkohan A, Mansoori B, Soleymani J, Ezzati Nazhad Dolatabadi J, Hamblin MR Tags: Colloids Surf B Biointerfaces Source Type: research