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Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Abstract Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concentration and activating some kinases, including PKG. The other mechanism of action involves induction of protein carbonylation. CO is known to directly and indirectly modulate the function of ion channels at the plasma membrane, which in turn have important repercussions in the cellular behavior. One gr...
Source: IUBMB Life - May 1, 2015 Category: Research Authors: Mauricio A. Retamal, Carmen G. León‐Paravic, Marcelo Ezquer, Fernando Ezquer, Rodrigo Del Rio, Amaury Pupo, Agustín D. Martínez, Carlos González Tags: Critical Review Source Type: research