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Evaluation of the Hemostatic Efficacy of Two Powdered Topical Absorbable Hemostats Using a Porcine Liver Abrasion Model of Mild to Moderate Bleeding.
CONCLUSION: Surgicel-P provided more effective and sustained hemostasis and faster TTH than Hemoblast-B. Surgicel-P represents a novel clinical alternative to provide adjunctive control of diffuse mild and moderate bleeding. Surgicel-P combines an ORC powder formulation and a delivery system in a device that is particularly useful for application on large surfaces and difficult-to-access anatomical locations where application of other forms of topical hemostats may be impractical. PMID: 32928005 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - September 18, 2020 Category: Surgery Tags: J Invest Surg Source Type: research

A Comparative Efficacy Evaluation of Recombinant Topical Thrombin (RECOTHROM ®) With A Gelatin Sponge Carrier Versus Topical Oxidized Regenerated Cellulose (TABOTAMP®/SURGICEL®) In A Porcine Liver Bleeding Model.
Conclusions: In this model, rT plus gelatin sponge carrier (active) was a more effective hemostat than ORC (passive) in both heparinized and non-heparinized animals. PMID: 31955627 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - January 22, 2020 Category: Surgery Tags: J Invest Surg Source Type: research

Experimental Evaluation of a New Tissue Factor-Based Topical Hemostat (TT-173) for Treatment of Hepatic Bleeding.
CONCLUSIONS: TT-173 shows favorable pharmacodynamic properties for improving hemostasis in partial liver resection which support further investigation of the product in this surgical indication. PMID: 30380352 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - November 2, 2018 Category: Surgery Tags: J Invest Surg Source Type: research

Potent Hemostatic Efficacy of a Novel Recombinant Fibrin Sealant Patch (KTF-374) in Rabbit Bleeding Models.
CONCLUSIONS: These results suggest that KTF-374 possesses more potent hemostatic properties than FCCF for various patterns of bleeding. KTF-374 is a promising hemostat due to its potent efficacy and good visibility of the wound site through the patch. PMID: 29260920 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - December 22, 2017 Category: Surgery Tags: J Invest Surg Source Type: research