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A Case Report of MPO-ANCA-Associated Vasculitis Following Heterologous mRNA1273 COVID-19 Booster Vaccination
J Korean Med Sci. 2022 Jul 4;37(26):e204. doi: 10.3346/jkms.2022.37.e204.ABSTRACTDespite that clinical trials have been examining the safety profile of coronavirus disease 2019 (COVID-19) vaccines, there are concerns about long-term side effects as the number of vaccinations increases. Herein, we report a case of new-onset renal-limited anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis after booster vaccination with the mRNA 1273 (Moderna) vaccine. A 72-year-old woman with no specific past history, and who had a normal renal function, developed ANCA-associated vasculitis following ...
Source: Journal of Korean Medical Science - July 5, 2022 Category: Biomedical Science Authors: Beop Chang Kim Han Seong Kim Kum Hyun Han Sang Youb Han Hyung Ah Jo Source Type: research

SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent in any previous coronavirus sequenced, resulting in striking mimicry of an identical FURIN-cleavable peptide on the human epithelial sodium channel α-subunit (ENaC-α). Genetic alteration of ENaC-α causes aldosterone dysregulation in patients, highlighting that the FURIN site is critical for activation of ENaC. Single cell RNA-seq from 65 studies shows significant overlap between expression of ENaC-α and the viral receptor ACE2 in cell types linked to the cardiovascular-renal-pulmonary pathophysiology of COVID-19. Triangulating this cellular char...
Source: eLife - May 26, 2020 Category: Biomedical Science Tags: Computational and Systems Biology Human Biology and Medicine Source Type: research