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Ferritin and Severe COVID-19, from Clinical Observations to Pathogenic Implications and Therapeutic Perspectives.
Authors: Ruscitti P, Giacomelli R Abstract BACKGROUND: A virally-induced cytokine storm syndrome, associated with a massive and overwhelming systemic inflammation, burdens a subgroup of patients with severe coronavirus disease-2019 (COVID-19), which leads to pulmonary inflammation and extensive lung damage. These severe COVID-19 patients are characterized by high ferritin levels. These findings mirror what was previously reported about the prognostic role of this iron storage protein in other inflammatory diseases included in the hyperferritinemic syndrome. The latter suggests that ferritin could be a further patho...
Source: The Israel Medical Association Journal - November 26, 2020 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation.
CONCLUSIONS: In this preliminary cross-sectional study, elevated ferritin levels were shown to correlate with disease severity in 39 patients from Israel with confirmed COVID-19 infection. Our results further strengthen the hypothesis that severe COVID-19 disease might be due to an underlying dysregulated hyperimmune response. In order to identify these patients early and prioritized resources, we believe that all patients with COVID-19 should be screened for hyperferritinemia. PMID: 33236582 [PubMed - in process]
Source: The Israel Medical Association Journal - November 26, 2020 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Ferritin and Severe COVID-19, from Clinical Observations to Pathogenic Implications and Therapeutic Perspectives.
Authors: Ruscitti P, Giacomelli R Abstract BACKGROUND: A virally-induced cytokine storm syndrome, associated with a massive and overwhelming systemic inflammation, burdens a subgroup of patients with severe coronavirus disease-2019 (COVID-19), which leads to pulmonary inflammation and extensive lung damage. These severe COVID-19 patients are characterized by high ferritin levels. These findings mirror what was previously reported about the prognostic role of this iron storage protein in other inflammatory diseases included in the hyperferritinemic syndrome. The latter suggests that ferritin could be a further patho...
Source: The Israel Medical Association Journal - August 21, 2020 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation.
CONCLUSIONS: In this preliminary cross-sectional study, elevated ferritin levels were shown to correlate with disease severity in 39 patients from Israel with confirmed COVID-19 infection. Our results further strengthen the hypothesis that severe COVID-19 disease might be due to an underlying dysregulated hyperimmune response. In order to identify these patients early and prioritized resources, we believe that all patients with COVID-19 should be screened for hyperferritinemia. PMID: 32812717 [PubMed - in process]
Source: The Israel Medical Association Journal - August 21, 2020 Category: General Medicine Tags: Isr Med Assoc J Source Type: research