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Viruses, Vol. 15, Pages 1759: Dynamic Evolution of SARS-CoV-2 in a Patient on Chemotherapy
We report here a case of B-cell acute lymphocytic leukemia on chemotherapy with infection of SARS-CoV-2 for more than two months. Genomic surveillance of his serial SARS-CoV-2-positive specimens revealed two unprecedented large deletions, Δ15–26 and Δ138–145, in the viral spike protein N-terminal domain (NTD) and demonstrated their dynamic shifts in generating these new variants. Located at antigenic supersites, these large deletions are anticipated to dramatically change the spike protein NTD in three-dimensional protein structure prediction, which may lead to immune...
Source: Viruses - August 18, 2023 Category: Virology Authors: Weihua Huang Changhong Yin Kimberly P. Briley William A. B. Dalzell John T. Fallon Tags: Communication Source Type: research

Viruses, Vol. 15, Pages 1449: Expert Consensus: Main Risk Factors for Poor Prognosis in COVID-19 and the Implications for Targeted Measures against SARS-CoV-2
Juan María González del Castillo Sarah Béatrice Heili Francisco Javier Martínez-Peromingo Rosario Menéndez Santiago Moreno José Luís Pablos Juan Pasquau José Luis Piñana The clinical evolution of patients infected with the Severe Acute Respiratory Coronavirus type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The evolution to less aggressive but better-transmitted viral variants, and the presence of immune memory responses in a growing number of vaccinated and/or virus-exposed individuals, has caused the pandemic to slowly wane in virulence. However, there are st...
Source: Viruses - June 27, 2023 Category: Virology Authors: Francisco Javier Candel Pablo Barreiro Miguel Salavert Alfonso Cabello Mario Fern ández-Ruiz Pedro P érez-Segura Jes ús San Román Juan Berenguer Ra úl Córdoba Rafael Delgado Pedro Pablo Espa ña Ignacio Alberto G ómez-Centurión Juan Mar ía Gonzá Tags: Systematic Review Source Type: research

Viruses, Vol. 15, Pages 377: SARS-CoV-2 Genome Variations in Viral Shedding of an Immunocompromised Patient with Non-Hodgkin & rsquo;s Lymphoma
Conclusions. This report shows that the multiple mutations that occur in an immunocompromised patient with persistent COVID-19 could provide information regarding viral evolution and emergence of new SARS-CoV-2 variants.
Source: Viruses - January 28, 2023 Category: Virology Authors: Rodrigo Villase ñor-Echavarri Laura Gomez-Romero Alexandra Martin-Onraet Luis A. Herrera Marco A. Escobar-Arrazola Oscar A. Ramirez-Vega Coraz ón Barrientos-Flores Alfredo Mendoza-Vargas Alfredo Hidalgo-Miranda Diana Vilar-Compte Alberto Cedro-Tanda Tags: Case Report Source Type: research