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Specialty: Biomedical Science
Source: Aging
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Total 122 results found since Jan 2013.
Single-cell RNA sequencing and multiple bioinformatics methods to identify the immunity and ferroptosis related biomarkers of SARS-CoV-2 infections to ischemic stroke
CONCLUSION: We believe these genes (B4GALT5, CRISPLD2, F5, ACSL1, CREB5) may regulate the immune response and ferroptosis of multiple immune cells, mainly including monocytes, which may contribute to the development of COVID-19-related IS. In addition, these genes may be potential targets for the treatment of COVID-19-related IS.PMID:37606960 | DOI:10.18632/aging.204966
Source: Aging - August 22, 2023 Category: Biomedical Science Authors: Xiang Zhao Qingyu Liang Hao Li Zhitao Jing Dongmei Pei Source Type: research
Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
Aging (Albany NY). 2023 Jun 7;15. doi: 10.18632/aging.204755. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, a phenomenon that suggest that organismal aging contributes to the fatality of the disease. In this regard, we and others have previously shown that COVID-19 severity correlates with shorter telomeres, a molecular determinant of aging, in patient's leukocytes. Lung injury is a predominant feature of acute SARS-CoV-2 infection that can furthe...
Source: Aging - June 9, 2023 Category: Biomedical Science Authors: Paula Mart ínez Ra úl Sánchez-Vazquez Arpita Saha Maria S Rodriguez-Duque Sara Naranjo-Gonzalo Joy S Osorio-Chavez Ana V Villar-Ramos Maria A Blasco Source Type: research
Humoral immunoresponse elicited against an adenoviral-based SARS-CoV-2 coronavirus vaccine in elderly patients
Aging (Albany NY). 2022 Sep 21;14(undefined). doi: 10.18632/aging.204299. Online ahead of print.ABSTRACTThe early sequencing of the SARS-CoV-2 viral genome allowed for a speedy development of effective vaccines against the virus. Nevertheless, age-related immunosenescence, the inability to mount strong immune responses, still represents a major obstacle. Here, in a group of 149 elderly volunteers (70-96 years old), evolution of the humoral immune response over time to Gam-COVID-Vac (Sputnik V), a vaccine based on heterologous recombinant adenovirus-26 (Ad26) and adenovirus-5 (Ad5) carrying the Spike genome, was analyzed by...
Source: Aging - September 24, 2022 Category: Biomedical Science Authors: Rodrigo Hern án Tomas-Grau Carolina Maldonado-Galdeano M ónica Aguilar López Esteban Vera Pingitore Patricia Aznar Mar ía Elena Alcorta Eva Mar ía Del Mar Vélez Agust ín Stagnetto Silvana Estefan ía Soliz-Santander C ésar Luís Ávila Sergio Benj Source Type: research
Emergency SARS-CoV-2 variants of concern: rapidly direct RT-qPCR detection without RNA extraction, clinical comparison, cost-effective, and high-throughput
Aging (Albany NY). 2022 Jun 2;14(undefined). doi: 10.18632/aging.204095. Online ahead of print.ABSTRACTSince the late 2020, the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has been characterized by the emergence of spike protein mutations, and these variants have become dominant worldwide. The gold standard SARS-CoV-2 diagnosis protocol requires two complex processes, namely, RNA extraction and real-time reverse transcriptase polymerase chain reaction (RT-PCR). There is a need for a faster, simpler, and more cost-effective detection strategy that can be utilized worldwide, ...
Source: Aging - June 3, 2022 Category: Biomedical Science Authors: Bing-Heng Yang Hsing-Yi Chung Li-Ting Kao Ming-Jr Jian Chih-Kai Chang Jung-Chung Lin Kuo-Ming Yeh Chien-Wen Chen Ya-Sung Yang Shan-Shan Hsieh Sheng-Hui Tang Cherng-Lih Perng Feng-Yee Chang Hung-Sheng Shang Source Type: research
The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China
CONCLUSIONS: The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant.PMID:35585022 | DOI:10.18632/aging.204085
Source: Aging - May 18, 2022 Category: Biomedical Science Authors: Xiao-Chun Song Xue-Hui Zhou Jing-Hui Cheng Wen-Hao Zhang Xiao Shen Huan Xu Shuai Nie Ji-Lai Xiao Fang Sun Chang Shu Jiu-Dong Chen Yan Tang Xiang Wang Xin-Pei Sun Jia-Kui Sun Ping Feng Qian-Kun Shi Source Type: research
Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
Aging (Albany NY). 2022 Feb 25;14(undefined). doi: 10.18632/aging.203915. Online ahead of print.ABSTRACTOld age is a crucial risk factor for severe coronavirus disease 2019 (COVID-19), with serious or fatal outcomes disproportionately affecting older adults compared with the rest of the population. We proposed that the physiological health status and biological age, beyond the chronological age itself, could be the driving trends affecting COVID-19 severity and mortality. A total of 155 participants hospitalized with confirmed COVID-19 aged 26-94 years were recruited for the study. Four different physiological summary indi...
Source: Aging - February 25, 2022 Category: Biomedical Science Authors: Irina Strazhesko Olga Tkacheva Daria Kashtanova Mikhail Ivanov Vladislav Kljashtorny Antonina Esakova Maria Karnaushkina Cassandra Guillemette Amber Hewett V éronique Legault Lilit Maytesian Maria Litvinova Alan Cohen Alexey Moskalev Source Type: research
Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling
Aging (Albany NY). 2022 Feb 4;14(undefined). doi: 10.18632/aging.203874. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has induced a worldwide pandemic since early 2020. COVID-19 causes pulmonary inflammation, secondary pulmonary fibrosis (PF); however, there are still no effective treatments for PF. The present study aimed to explore the inhibitory effect of dihydroartemisinin (DHA) on pulmonary inflammation and PF, and its molecular mechanism. Morphological changes and collagen deposition were analyzed using hematoxylin-eosin staining, Masson staining, and the hydroxyproline con...
Source: Aging - February 4, 2022 Category: Biomedical Science Authors: Xiaolan You Xingyu Jiang Chuanmeng Zhang Kejia Jiang Xiaojun Zhao Ting Guo Xiaowei Zhu Jingjing Bao Hongmei Dou Source Type: research
Severe versus common COVID-19: an early warning nomogram model
In this study, we establish an early warning nomogram model related to severe versus common COVID-19. A total of 1059 COVID-19 patients were analyzed in the primary cohort and divided into common and severe according to the guidelines on the Diagnosis and Treatment of COVID-19 by the National Health Commission of China (7th version). The clinical data were collected for logistic regression analysis to assess the risk factors for severe versus common type. Furthermore, 123 COVID-19 patients were reviewed as the validation cohort to assess the performance of this model. Multivariate logistic analysis revealed that age, dyspn...
Source: Aging - January 17, 2022 Category: Biomedical Science Authors: Yanxin Chang Xuying Wan Xiaohui Fu Ziyu Yang Zhijie Lu Zhenmeng Wang Li Fu Lei Yin Yongjie Zhang Qian Zhang Source Type: research
