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Viruses, Vol. 15, Pages 1577: Synergistic Activity of Remdesivir & ndash;Nirmatrelvir Combination on a SARS-CoV-2 In Vitro Model and a Case Report
Conclusions: Remdesivir–nirmatrelvir combination has synergic activity in vitro. This combination may have a role in immunosuppressed patients with severe COVID-19 and prolonged viral shedding.
Source: Viruses - July 19, 2023 Category: Virology Authors: Anna Gidari Samuele Sabbatini Elisabetta Schiaroli Sabrina Bastianelli Sara Pierucci Chiara Busti Lavinia Maria Saraca Luca Capogrossi Maria Bruna Pasticci Daniela Francisci Tags: Article Source Type: research

Viruses, Vol. 13, Pages 503: Treatment Protocol for COVID-19 Based on T2R Phenotype
P. Barham COVID-19 has become a global pandemic of the highest priority. Multiple treatment protocols have been proposed worldwide with no definitive answer for acure. A prior retrospective study showed association between bitter taste receptor 38 (T2R38) phenotypes and the severity of COVID-19. Based on this, we proposed assessing the different T2R38 phenotypes response towards a targeted treatment protocol. Starting July 2020 till December 2020, we tested subjects for T2R38 phenotypic expression (supertasters, tasters, and nontasters). Subjects who were subsequently infected with severe acute respiratory syndrome cor...
Source: Viruses - March 18, 2021 Category: Virology Authors: Mohamed A. Taha Christian A. Hall Colin J. Shortess Richard F. Rathbone Henry P. Barham Tags: Article Source Type: research

Viruses, Vol. 13, Pages 413: Pharmacogenetics Approach for the Improvement of COVID-19 Treatment
ia The treatment of coronavirus disease 2019 (COVID-19) has been a challenge. The efficacy of several drugs has been evaluated and variability in drug response has been observed. Pharmacogenetics could explain this variation and improve patients’ outcomes with this complex disease; nevertheless, several disease-related issues must be carefully reviewed in the pharmacogenetic study of COVID-19 treatment. We aimed to describe the pharmacogenetic variants reported for drugs used for COVID-19 treatment (remdesivir, oseltamivir, lopinavir, ritonavir, azithromycin, chloroquine, hydroxychloroquine, ivermectin, and dexametha...
Source: Viruses - March 5, 2021 Category: Virology Authors: Ingrid Fricke-Galindo Ramc és Falfán-Valencia Tags: Review Source Type: research

Viruses, Vol. 13, Pages 309: Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin –Kallikrein System in Severe COVID-19
Conclusions: In this small cohort, we found evidence for safety and a beneficial role of pharmacological inhibition of the kinin–kallikrein system in two markers that indicate improved disease recovery.
Source: Viruses - February 16, 2021 Category: Virology Authors: Eli Mansour Andre C. Palma Raisa G. Ulaf Luciana C. Ribeiro Ana Flavia Bernardes Thyago A. Nunes Marcus V. Agrela Bruna Bombassaro Milena Monfort-Pires Rafael L. Camargo Eliana P. Araujo Natalia S. Brunetti Alessandro S. Farias Ant ônio Luís E. Falcão Tags: Article Source Type: research

Viruses, Vol. 12, Pages 1092: Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review
Kar The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care systems around the world. Scientists and pharmaceutical companies have promptly responded by advancing potential therapeutics into clinical trials at an exponential rate. Initial encouraging results have been realized using remdesivir and dexamethasone. Yet, the research continues so as to identify better clinically relevant therapeutics that act either as prophylactics to prevent the infection or as treatments to limit the severity of COVID-19 and substantially decrease the mortality rate. Previously, we reviewed the potential ther...
Source: Viruses - September 25, 2020 Category: Virology Authors: Rami A. Al-Horani Srabani Kar Tags: Review Source Type: research