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Viruses, Vol. 14, Pages 787: Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients
a Gabeta George Ntaios George N. Dalekos Risk stratification of coronavirus disease-19 (COVID-19) patients by simple markers is critical to guide treatment. We studied the predictive value of soluble interleukin-2 receptor (sIL-2R) for the early identification of patients at risk of developing severe clinical outcomes. sIL-2R levels were measured in 197 patients (60.9% males; median age 61 years; moderate disease, n = 65; severe, n = 132, intubated and/or died, n = 42). All patients received combined immunotherapies (anakinra ± corticosteroids ± intravenous immunoglobulin &plus...
Source: Viruses - April 10, 2022 Category: Virology Authors: Nikolaos K. Gatselis Vasiliki Lygoura Aggeliki Lyberopoulou George Giannoulis Anna Samakidou Antonia Vaiou George Vatidis Katerina Antoniou Aggelos Stefos Sarah Georgiadou Dimitrios Sagris Dafni Sveroni Despoina Stergioula Stella Gabeta George Ntaios Geor Tags: Article Source Type: research

Viruses, Vol. 13, Pages 2212: Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease
ues Fournie The detailed characterization of human γδ T lymphocyte differentiation at the single-cell transcriptomic (scRNAseq) level in tumors and patients with coronavirus disease 2019 (COVID-19) requires both a reference differentiation trajectory of γδ T cells and a robust mapping method for additional γδ T lymphocytes. Here, we incepted such a method to characterize thousands of γδ T lymphocytes from (n = 95) patients with cancer or adult and pediatric COVID-19 disease. We found that cancer patients with human papillomavirus-positive head and neck squamous cell carcinoma and Epstein–Barr virus-positive H...
Source: Viruses - November 3, 2021 Category: Virology Authors: Juan Pablo Cerapio Marion Perrier Fr éderic Pont Marie Tosolini Camille Laurent St éphane Bertani Jean-Jacques Fournie Tags: Article Source Type: research

Viruses, Vol. 12, Pages 705: Repurposing Therapeutics for Potential Treatment of SARS-CoV-2: A Review
. L. Declan The need for proven disease-specific treatments for the novel pandemic coronavirus SARS-CoV-2 necessitates a worldwide search for therapeutic options. Since the SARS-CoV-2 virus shares extensive homology with SARS-CoV and MERS-CoV, effective therapies for SARS-CoV and MERS-CoV may also have therapeutic potential for the current COVID-19 outbreak. To identify therapeutics that might be repositioned for treatment of the SARS-CoV-2 disease COVID-19, we strategically reviewed the literature to identify existing therapeutics with evidence of efficacy for the treatment of the three coronaviruses that cause severe...
Source: Viruses - June 29, 2020 Category: Virology Authors: Jennifer Santos Stephanie Brierley Mohit J. Gandhi Michael A. Cohen Phillip C. Moschella Arwen B. L. Declan Tags: Review Source Type: research