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Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
Aging (Albany NY). 2023 Jun 7;15. doi: 10.18632/aging.204755. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, a phenomenon that suggest that organismal aging contributes to the fatality of the disease. In this regard, we and others have previously shown that COVID-19 severity correlates with shorter telomeres, a molecular determinant of aging, in patient's leukocytes. Lung injury is a predominant feature of acute SARS-CoV-2 infection that can furthe...
Source: Aging - June 9, 2023 Category: Biomedical Science Authors: Paula Mart ínez Ra úl Sánchez-Vazquez Arpita Saha Maria S Rodriguez-Duque Sara Naranjo-Gonzalo Joy S Osorio-Chavez Ana V Villar-Ramos Maria A Blasco Source Type: research

Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltration
This study was designed to explore the expression status, prognostic significance and molecular functions of TMPRSS2 in lung cancer. TMPRSS2 expression was investigated using the TIMER, Oncomine, UALCAN, GEO, HPA and TCGA databases. The prognostic value of TMPRSS2 was examined using Cox regression and a nomogram. KEGG, GO and GSEA were performed to investigate the cellular function of TMPRSS2 in lung cancer. The relationship between TMPRSS2 and immune infiltration was determined using the TIMER and CIBERSORT algorithms. TMPRSS2 mRNA and protein expression was significantly reduced in lung cancer. Decreased TMPRSS2 expressi...
Source: Aging - January 12, 2022 Category: Biomedical Science Authors: Xiaopeng Liu Bing Liu Yanan Shang Pengxiu Cao Jiajie Hou Fei Chen Bo Zhang Yumei Fan Ke Tan Source Type: research

< em > In silico < /em > analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients
Aging (Albany NY). 2021 Jun 24;13. doi: 10.18632/aging.203159. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), and is highly contagious and pathogenic. TMPRSS2 and Neuropilin-1, the key components that facilitate SARS-CoV-2 infection, are potential targets for treatment of COVID-19. Here we performed a comprehensive analysis on NRP1 and TMPRSS2 in lung to provide information for treating comorbidity of COVID-19 with lung cancer. NRP1 is widely expressed across all the human tissues while TMPRSS2 is expressed in a restricted pattern. ...
Source: Aging - June 25, 2021 Category: Biomedical Science Authors: Song Hu Zheyu Hu Jiajia Qin Chuwen Lin Xuan Jiang Source Type: research