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Viruses, Vol. 14, Pages 611: A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins
ampos Kyle J. Roux The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SARS-CoV-2 viral proteins was studied by global proteomic analysis, and proximity biotinylation (BioID) was used to map the SARS-CoV-2 virus–host interactome in human lung cancer-derived cells. Functional enrichment analyses revealed previously...
Source: Viruses - March 15, 2022 Category: Virology Authors: Danielle G. May Laura Martin-Sancho Valesca Anschau Sophie Liu Rachel J. Chrisopulos Kelsey L. Scott Charles T. Halfmann Ramon D íaz Peña Dexter Pratt Alexandre R. Campos Kyle J. Roux Tags: Article Source Type: research