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Viruses, Vol. 15, Pages 1759: Dynamic Evolution of SARS-CoV-2 in a Patient on Chemotherapy
We report here a case of B-cell acute lymphocytic leukemia on chemotherapy with infection of SARS-CoV-2 for more than two months. Genomic surveillance of his serial SARS-CoV-2-positive specimens revealed two unprecedented large deletions, Δ15–26 and Δ138–145, in the viral spike protein N-terminal domain (NTD) and demonstrated their dynamic shifts in generating these new variants. Located at antigenic supersites, these large deletions are anticipated to dramatically change the spike protein NTD in three-dimensional protein structure prediction, which may lead to immune...
Source: Viruses - August 18, 2023 Category: Virology Authors: Weihua Huang Changhong Yin Kimberly P. Briley William A. B. Dalzell John T. Fallon Tags: Communication Source Type: research

Viruses, Vol. 15, Pages 1531: Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020 & ndash;2022
Viruses, Vol. 15, Pages 1531: Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020–2022 Viruses doi: 10.3390/v15071531 Authors: Mirjam B. H. M. Duijvestijn Nancy N. M. P. Schuurman Johannes C. M. Vernooij Michelle A. J. M. van Leeuwen Berend-Jan Bosch Judith M. A. van den Brand Jaap A. Wagenaar Frank J. M. van Kuppeveld Herman F. Egberink Josanne H. Verhagen Stray cats can host (zoonotic) viral pathogens and act as a source of infection for domestic cats or humans. In this cross-sectional (sero)prevalence study, s...
Source: Viruses - July 12, 2023 Category: Virology Authors: Mirjam B. H. M. Duijvestijn Nancy N. M. P. Schuurman Johannes C. M. Vernooij Michelle A. J. M. van Leeuwen Berend-Jan Bosch Judith M. A. van den Brand Jaap A. Wagenaar Frank J. M. van Kuppeveld Herman F. Egberink Josanne H. Verhagen Tags: Article Source Type: research

Viruses, Vol. 15, Pages 693: Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab & mdash;Challenging Recognition and Treatment
We present a case report of a patient with follicular lymphoma, treated with obinutuzumab, who was diagnosed with prolonged, ongoing SARS-CoV-2 infection and related organizing pneumonia. The recognition and the treatment were challenging which makes this case noteworthy. Antiviral therapy with several medications was administrated to our patient and their temporary, positive effect was observed. Moreover, high-dose intravenous immunoglobulin was applied, because slowly decreasing IgM and IgG levels were observed. The patient also received standard treatment of organizing pneumonia. We believe that such a complex approach ...
Source: Viruses - March 7, 2023 Category: Virology Authors: E. Łyżwa M. Sobiecka K. Lewandowska I. Siemion-Szcze śniak I. Bara ńska M. Klatt R. Langfort M. Szturmowicz W. Tomkowski Tags: Case Report Source Type: research