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Viruses, Vol. 15, Pages 1952: Real-World Experience of the Comparative Effectiveness and Safety of Combination Therapy with Remdesivir and Monoclonal Antibodies versus Remdesivir Alone for Patients with Mild-to-Moderate COVID-19 and Immunosuppression: A Retrospective Single-Center Study in Aichi, Japan
Hiroshige Mikamo The coronavirus disease (COVID-19) pandemic continues to threaten global public health. Remdesivir and monoclonal antibodies have shown promise for COVID-19 treatment of patients who are immunocompromised, including those with cancer, transplant recipients, and those with autoimmune disorder. However, the effectiveness and safety of this combination therapy for patients who are immunosuppressed remain unclear. We compared the efficacy and safety of combination therapy and remdesivir monotherapy for patients with mild-to-moderate COVID-19 who were immunosuppressed. Eighty-six patients treated in July 2...
Source: Viruses - September 19, 2023 Category: Virology Authors: Jun Hirai Nobuaki Mori Daisuke Sakanashi Wataru Ohashi Yuichi Shibata Nobuhiro Asai Hideo Kato Mao Hagihara Hiroshige Mikamo Tags: Article Source Type: research

Viruses, Vol. 15, Pages 614: Rational Use of Monoclonal Antibodies as Therapeutic Treatment in an Oncologic Patient with Long COVID
This study highlights the Evusheld monoclonal antibodies’ efficacy, not only in prevention but also in successful therapy against prolonged COVID-19. Therefore, testing neutralizing monoclonal antibodies in vitro against SARS-CoV-2 mutants directly isolated from patients could provide useful information for the treatment of people affected by long COVID.
Source: Viruses - February 23, 2023 Category: Virology Authors: Maria Grazia Cusi Anna Maria Di Giacomo Gabriele Anichini Gianni Gori Savellini Chiara Terrosi Claudia Gandolfo Michele Maio Tags: Case Report Source Type: research

Viruses, Vol. 15, Pages 377: SARS-CoV-2 Genome Variations in Viral Shedding of an Immunocompromised Patient with Non-Hodgkin & rsquo;s Lymphoma
Conclusions. This report shows that the multiple mutations that occur in an immunocompromised patient with persistent COVID-19 could provide information regarding viral evolution and emergence of new SARS-CoV-2 variants.
Source: Viruses - January 28, 2023 Category: Virology Authors: Rodrigo Villase ñor-Echavarri Laura Gomez-Romero Alexandra Martin-Onraet Luis A. Herrera Marco A. Escobar-Arrazola Oscar A. Ramirez-Vega Coraz ón Barrientos-Flores Alfredo Mendoza-Vargas Alfredo Hidalgo-Miranda Diana Vilar-Compte Alberto Cedro-Tanda Tags: Case Report Source Type: research

Viruses, Vol. 14, Pages 2754: Identification and Characterization of Cell Lines HepG2, Hep3B217 and SNU387 as Models for Porcine Epidemic Diarrhea Coronavirus Infection
In this study, we present an approach to identify suitable permissive cell lines for PEDV research. Human cell lines were screened for a high correlation coefficient with the established PEDV infection model Huh7 based on RNA-seq data from the Cancer Cell Line Encyclopedia (CCLE). Experimentally testing permissiveness towards PEDV infection, three highly permissive human cell lines, HepG2, Hep3B217, and SNU387 were identified. The replication kinetics of PEDV in HepG2, Hep3B217, and SNU387 cells were similar to that in Vero and Huh7 cells. Additionally, the transcriptomes analysis showed robust induction of transcripts ass...
Source: Viruses - December 10, 2022 Category: Virology Authors: Lilei Lv Huaye Luo Lingxue Yu Wu Tong Yifeng Jiang Guoxin Li Guangzhi Tong Yanhua Li Changlong Liu Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2728: Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients
rooke COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), is estimated to have caused over 6.5 million deaths worldwide. The emergence of fast-evolving SARS-CoV-2 variants of concern alongside increased transmissibility and/or virulence, as well as immune and vaccine escape capabilities, highlight the urgent need for more effective antivirals to combat the disease in the long run along with regularly updated vaccine boosters. One of the early risk factors identified during the COVID-19 pandemic was that men are more likely to become infected by the virus, more likely to develop severe ...
Source: Viruses - December 7, 2022 Category: Virology Authors: Efstathios S. Giotis Emine Cil Greg N. Brooke Tags: Review Source Type: research

Viruses, Vol. 14, Pages 1166: & gamma; & delta; T Cells in Emerging Viral Infection: An Overview
Viruses, Vol. 14, Pages 1166: γδ T Cells in Emerging Viral Infection: An Overview Viruses doi: 10.3390/v14061166 Authors: Eleonora Cimini Chiara Agrati New emerging viruses belonging to the Coronaviridae, Flaviviridae, and Filoviridae families are serious threats to public health and represent a global concern. The surveillance to monitor the emergence of new viruses and their transmission is an important target for public health authorities. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an excellent example of a pathogen able to cause a pandemic. In a few months, SARS-CoV-2 ...
Source: Viruses - May 27, 2022 Category: Virology Authors: Eleonora Cimini Chiara Agrati Tags: Review Source Type: research

Viruses, Vol. 14, Pages 928: A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses
Zeng Cai Ke Xu New strategies to rapidly develop broad-spectrum antiviral therapies are urgently required for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the universal host factors necessary for viral replication are the most promising approach, with broad-spectrum, foresighted function, and low resistance. We and others recently identified that host dihydroorotate dehydrogenase (DHODH) is one of the universal host factors essential for the replication of many acute-infectious viruses. DHODH is a rate-limiting enzyme catalyzing the fourth step in de novo pyrimidine synthesis. The...
Source: Viruses - April 28, 2022 Category: Virology Authors: Yucheng Zheng Shiliang Li Kun Song Jiajie Ye Wenkang Li Yifan Zhong Ziyan Feng Simeng Liang Zeng Cai Ke Xu Tags: Review Source Type: research

Viruses, Vol. 14, Pages 611: A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins
ampos Kyle J. Roux The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SARS-CoV-2 viral proteins was studied by global proteomic analysis, and proximity biotinylation (BioID) was used to map the SARS-CoV-2 virus–host interactome in human lung cancer-derived cells. Functional enrichment analyses revealed previously...
Source: Viruses - March 15, 2022 Category: Virology Authors: Danielle G. May Laura Martin-Sancho Valesca Anschau Sophie Liu Rachel J. Chrisopulos Kelsey L. Scott Charles T. Halfmann Ramon D íaz Peña Dexter Pratt Alexandre R. Campos Kyle J. Roux Tags: Article Source Type: research

Viruses, Vol. 14, Pages 25: Pandemics of the 21st Century: The Risk Factor for Obese People
¡ The number of obese adults and children is increasing worldwide, with obesity now being a global epidemic. Around 2.8 million people die annually from clinical overweight or obesity. Obesity is associated with numerous comorbid conditions including hypertension, cardiovascular disease, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia, nonalcoholic fatty liver disease, and cancer, and even the development of severe disease after infection with viruses. Over the past twenty years, a number of new viruses has emerged and entered the human population. Moreover, influenza (H1N1)pdm09 virus and severe acute resp...
Source: Viruses - December 23, 2021 Category: Virology Authors: Miriam Hanckov á Tatiana Bet áková Tags: Review Source Type: research

Viruses, Vol. 13, Pages 2212: Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease
ues Fournie The detailed characterization of human γδ T lymphocyte differentiation at the single-cell transcriptomic (scRNAseq) level in tumors and patients with coronavirus disease 2019 (COVID-19) requires both a reference differentiation trajectory of γδ T cells and a robust mapping method for additional γδ T lymphocytes. Here, we incepted such a method to characterize thousands of γδ T lymphocytes from (n = 95) patients with cancer or adult and pediatric COVID-19 disease. We found that cancer patients with human papillomavirus-positive head and neck squamous cell carcinoma and Epstein–Barr virus-positive H...
Source: Viruses - November 3, 2021 Category: Virology Authors: Juan Pablo Cerapio Marion Perrier Fr éderic Pont Marie Tosolini Camille Laurent St éphane Bertani Jean-Jacques Fournie Tags: Article Source Type: research

Viruses, Vol. 13, Pages 751: Within-Host and Between-Host Evolution in SARS-CoV-2 —New Variant’s Source
Viruses, Vol. 13, Pages 751: Within-Host and Between-Host Evolution in SARS-CoV-2—New Variant’s Source Viruses doi: 10.3390/v13050751 Authors: Karin Moelling Some of the newly emerging corona viral variants show high numbers of mutations. This is unexpected for a virus with a low mutation rate due to an inherent proof-reading system. Could such a variant arise under very special conditions occurring in a host where the virus replicates and mutates in a rather unlimited fashion, such as in immune compromised patients? The virus was shown to replicate in an immunosuppressed cancer patient for more than 105 days a...
Source: Viruses - April 25, 2021 Category: Virology Authors: Karin Moelling Tags: Opinion Source Type: research