Great new chapter of WormBook in GENETICS!
There’s a great new chapter of WormBook in GENETICS by Meera V. Sundaram and Matthew Buechner: The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and Plasticity.
Abstract
The excretory system of the nematode Caenorhabditis elegans is a superb model of tubular organogenesis involving a minimum of cells. The system consists of just three unicellular tubes (canal, duct, and pore), a secretory gland, and two associated neurons. Just as in more complex organs, cells of the excretory system must first adopt specific identities and then coordinate diverse processes to form tubes...
Source: WormBase - May 5, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication external website news wormbook Source Type: news
New version of Worm Breeder ’s Gazette!
Dear Worm Breeders —
We are pleased to announce the next iteration of the Worm Breeder’s Gazette with some exciting new changes.
Starting today, the Gazette will publish articles on a rolling basis with only a brief editorial period to review formatting. We’ve also made the submission process simpler and more robust. For example, you can start a submission online, saving your progress at any time to complete later.
By accelerating the availability of Gazette articles, we seek to preserve the original spirit of the Gazette: publication of breaking results and new methods of general interest to the communit...
Source: WormBase - April 26, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news Source Type: news
New version of Worm Breeder’s Gazette!
Dear Worm Breeders —
We are pleased to announce the next iteration of the Worm Breeder’s Gazette with some exciting new changes.
Starting today, the Gazette will publish articles on a rolling basis with only a brief editorial period to review formatting. We’ve also made the submission process simpler and more robust. For example, you can start a submission online, saving your progress at any time to complete later.
By accelerating the availability of Gazette articles, we seek to preserve the original spirit of the Gazette: publication of breaking results and new methods of general interest to the communit...
Source: WormBase - April 26, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news Source Type: news
May 2016: 8 new labs joining the community
8 new labs have registered with WormBase and the CGC. Please join us in welcoming these labs to the community!
Alex Mendenhall
ARM
wam
University of Washington, Seattle, WA
Hiroaki Miki
CRB
dcr
Osaka University, Osaka, Japan
website
Megan Hwa Brewer
MHB
nna
Sydney Medical School, Concord, NSW, Australia
Suhong Xu
SHX
zju
Zhejiang University, Hangzhou, Zhejiang, China
website
Tamara Mikeladze-Dvali
TMD
mik
Biozentrum der LMU Mnchen, Planegg-Martinsried, Germany
website
Matt Crook
TWP
mxc
Whitman College, Walla Walla, WA
Anna K Allen
WDC
ana
Howard University, Washington, DC
website
Wolfgang Fischle
WFK
cbd
M...
Source: WormBase - April 25, 2016 Category: Genetics & Stem Cells Authors: Todd Harris Tags: Uncategorized Source Type: news
Check out the new CRISPR guide RNA selection tool!
CRISPR/Cas9 is the current technology of choice for genome editing! Check out the tool for the selection of CRISPR guide RNAs here. (Source: WormBase)
Source: WormBase - April 13, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication external website news Source Type: news
Nichol Thomson passes away
Nichol Thomson, one of the founding figures of C. elegans research, recently passed away, peacefully, at the age of 91, on 26th March 2016. He was responsible for a major part of all the early electron microscopy work on the worm, and indeed his initial results with fixing and sectioning C. elegans samples were decisive in persuading Sydney Brenner to work on C. elegans rather than some other nematode. Nichol was an important influence, inspiration, colleague and friend to all of the C. elegans researchers at MRC-LMB in Cambridge UK, from 1964 until his retirement in 1989. (Source: WormBase)
Source: WormBase - April 12, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news Source Type: news
Nicol Thomson passes away
Nichol Thomson, one of the founding figures of C. elegans research, recently passed away, peacefully, at the age of 91, on 26th March 2016. He was responsible for a major part of all the early electron microscopy work on the worm, and indeed his initial results with fixing and sectioning C. elegans samples were decisive in persuading Sydney Brenner to work on C. elegans rather than some other nematode. Nichol was a important influence, inspiration, colleague and friend to all of the C. elegans researchers at MRC-LMB in Cambridge UK, from 1964 until his retirement in 1989. (Source: WormBase)
Source: WormBase - April 12, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news Source Type: news
Check out the first chapter of WormBook in GENETICS!
The first chapter of WormBook in GENETICS, CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering, by Daniel J. Dickinson and Bob Goldstein, is now available!
Abstract
The advent of genome editing techniques based on the clustered regularly interspersed short palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the biological sciences. CRISPR is quickly becoming an indispensible experimental tool for researchers using genetic model organisms, including the nematode Caenorhabditis elegans. Here, we provide an overview of CRISPR-based strategies for genome editing in C. elegans. We focus on p...
Source: WormBase - March 16, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication community external website news Source Type: news
Featured Paper: Allergy the Price of Immunity
We would like to draw your attention to a paper recently published in PLOS Computational Biology: Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity by Nidhi Tyagi, et. al.
It is thought that part of our immune system has evolved to combat and provide immunity against infection by parasitic worms. However, in the absence of parasitic infection, this same arm of the immune system can become hyper-responsive and mistakenly target allergenic proteins in food or the environment. This results in an unregulated allergic response, which can sometimes be lethal.
The researchers used computatio...
Source: WormBase - March 8, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: Featured Papers news paper of interest Source Type: news
Leonid Kruglyak honored with 2016 Novitski Prize
Leonid Kruglyak (HHMI/University of California, Los Angeles) has been awarded the 2016 Edward Novitski Prize for his extraordinary level of creativity and intellectual ingenuity in the solution of significant problems in genetics research. Read more here. (Source: WormBase)
Source: WormBase - March 2, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news award prize Source Type: news
Please cite WormBase in your publications!
If you have used WormBase in the planning, design, execution, analysis, or reporting of research, please cite WormBase in your publications, preferably please cite which version/release of WormBase you used. See details on how to cite WormBase. (Source: WormBase)
Source: WormBase - February 29, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news Source Type: news
Need to order a clone or plasmid?
Are you looking for a clone or plasmid? Please note that WormBase does not house or distribute reagents but maintains a reagents page with links to the primary resources that generate and/or distribute reagents. Visit the reagents page to learn about resources that distribute clones, plasmids, RNA libraries, etc. This page can also be accessed from a drop-down from the ‘Resources’ section on the menu bar at the top of the WormBase home page. (Source: WormBase)
Source: WormBase - February 25, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication news reagent Source Type: news
Passing of Robert Stuart (Bob) Edgar, (1930 – 2016)
One of the pioneer spirits of our field, Bob Edgar, has died. Bob started the Worm Breeder’s Gazette in 1975 and helped organize early worm meetings. He played an essential role in fostering the collegiality that has distinguished the C. elegans field. (Source: WormBase)
Source: WormBase - February 18, 2016 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: news Uncategorized Source Type: news
Creating Hi-Res Screenshots in JBrowse
While the new genome browser (JBrowse) implemented at WormBase has several advantages, like faster browsing and a faceted track selector, it does lack a few features from the venerable GBrowse instance that has been at WormBase for many years. While we and the JBrowse developers are working on addressing those minor shortcomings, this article is about how to circumvent one of those issues now.
JBrowse lacks the ability to make a high resolution image like GBrowse. While taking a screenshot can sometimes result in an acceptable image (for example, Macs with a retina display work pretty well), the result is not always...
Source: WormBase - February 10, 2016 Category: Genetics & Stem Cells Authors: Scott Cain Tags: brief communication bioinformatics genome browsers jbrowse tools tutorials Source Type: news
Are you a worm lab PI or “lab head”? Be sure to join the new mailing list.
Are you a principal investigator or lab head? By now you should have received not one, not two, but three invitations to join a new low-traffic mailing list.
This list serves as a communication channel for the newly formed Worm Board to announce initiatives related to community support and infrastructure.
If you have not already accepted the invitation to join, please check your inbox. If you did not receive an invite, you cannot find it, it has expired, or you think you should be included on the list, you may send a subscription request at the home page of the mailing list.
Please add a brief description of who you are wi...
Source: WormBase - January 15, 2016 Category: Genetics & Stem Cells Authors: Todd Harris Tags: news wormboard Source Type: news
