Genotype-Tissue Expression project expands functional studies of genomic variation
The National Institutes of Health has awarded eight grants as part of the Genotype-Tissue Expression (GTEx) project to explore how human genes are expressed and regulated in different tissues, and the role that genomic variation plays in modulating that expression. The GTEx awards will contribute to a resource database and tissue bank that researchers can use to study how inherited genomic variants - inherited spelling changes in the DNA code - may influence gene activity and lead to disease. The grants will add data from analyses of tissue samples whose collection began in 2010, as well as expand the resource database and...
Source: NHGRI Press Releases - August 1, 2014 Category: Genetics & Stem Cells Source Type: news
NIH awards $14.5 million to research groups studying newest DNA sequencing techniques
A number of micro-sized technologies - such as nanopores and microfluidics - are among the approaches researchers will use to develop high quality, low cost DNA sequencing technology through new grants from the National Institutes of Health. The grants, which total approximately $14.5 million to eight research teams over two to four years as funds become available, are the last to be awarded by the Advanced DNA Sequencing Technology program of the National Human Genome Research Institute (NHGRI), a part of NIH. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - August 1, 2014 Category: Genetics & Stem Cells Source Type: news
NIH awards two new grants to explore the understanding of genomics research in Africa
Two grants totaling more than $300,000 will support studies on genomic literacy among Africans as it relates to research conducted in Africa by African investigators. The three-year grants are part of the Human Heredity and Health in Africa (H3Africa) program, funded by the National Institutes of Health's Common Fund in partnership with Britain's Wellcome Trust. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - August 1, 2014 Category: Genetics & Stem Cells Source Type: news
TCGA researchers identify four subtypes of stomach cancer
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas (TCGA) Network have found. In the study, published online July 23, 2014, in Nature, the scientists report that this discovery could change how researchers think about developing treatments for stomach cancer, also called gastric cancers or gastric adenocarcinomas. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - July 23, 2014 Category: Genetics & Stem Cells Source Type: news
Study identifies novel genomic changes in the most common type of lung cancer
Researchers from The Cancer Genome Atlas (TCGA) Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer. �Knowledge of these genomic changes may expand the number of possible therapeutic targets for this disease and potentially identify a greater number of patients with treatable mutations because many potent cancer drugs that target these mutations already exist. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - July 9, 2014 Category: Genetics & Stem Cells Source Type: news
NIH funds next step of cutting-edge research into Alzheimer's disease genome
Teams of scientists will use support from the National Institutes of Health to conduct research into the genetic underpinnings of Alzheimer's disease, analyzing how genome sequences-the order of chemical letters in a cell's DNA-may contribute to increased risk or protect against the disease. The NIH awarded grants for using innovative new technologies and computational methods for the analysis. The scientists also will seek insights into why some people with known risks do not develop the disease. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - July 7, 2014 Category: Genetics & Stem Cells Source Type: news
NIH funds next step of cutting-edge research into Alzheimer's disease genome
Teams of scientists will use support from the National Institutes of Health to conduct research into the genetic underpinnings of Alzheimer's disease, analyzing how genome sequences-the order of chemical letters in a cell's DNA-may contribute to increased risk or protect against the disease. The NIH awarded grants for using innovative new technologies and computational methods for the analysis. The scientists also will seek insights into why some people with known risks do not develop the disease. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - July 7, 2014 Category: Genetics & Stem Cells Source Type: news
NIH names new clinical sites in Undiagnosed Diseases Network
Researchers for the first time have used a combination of microfluidics and genomics to fish out a specific gut bacterium from the sea of trillions of microbes in the human microbiome. The new method has broad applications for isolating and studying many now impossible or hard-to-grow microorganisms implicated in health and disease, according to a study published online the week of June 23, 2014, in the Proceedings of the National Academy of Sciences. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - July 1, 2014 Category: Genetics & Stem Cells Source Type: news
MEDIA AVAILABILITY: New approach may improve study of hard-to-grow, disease-related microorganisms
Researchers for the first time have used a combination of microfluidics and genomics to fish out a specific gut bacterium from the sea of trillions of microbes in the human microbiome. The new method has broad applications for isolating and studying many now impossible or hard-to-grow microorganisms implicated in health and disease, according to a study published online the week of June 23, 2014, in the Proceedings of the National Academy of Sciences. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - June 27, 2014 Category: Genetics & Stem Cells Source Type: news
New report offers a primer for doctors' use of clinical genome and exome sequencing
Sooner than almost anyone expected, a new, genome-based technology for demystifying undiagnosed illnesses-particularly rare childhood diseases-is moving from research laboratories into general medical practice. Now, two leading scientists have sketched out what doctors need to know in order to use the new technology effectively. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - June 18, 2014 Category: Genetics & Stem Cells Source Type: news
New report offers a primer for doctors' use of clinical genome and exome sequencing
Sooner than almost anyone expected, a new, genome-based technology for demystifying undiagnosed illnesses-particularly rare childhood diseases-is moving from research laboratories into general medical practice. Now, two leading scientists have sketched out what doctors need to know in order to use the new technology effectively. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - June 18, 2014 Category: Genetics & Stem Cells Source Type: news
Media Availability: New approach to analyzing tumor genome promises expanded results
Researchers have created a promising new method to accurately and, in some cases, more comprehensively analyze and interpret DNA sequence information from cancer patients. They have developed an algorithm that sorts out genomic mutations and variations and ranks them according to their clinical and biological relevance to a patient's cancer. The findings eventually may help guide individualized patient treatment or enrollment in clinical trials that test a therapy aimed at a particular genomic alteration. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - May 19, 2014 Category: Genetics & Stem Cells Source Type: news
Researchers discover underlying genetics, marker for stroke, cardiovascular disease
Scientists studying the genomes of nearly 5,000 people have pinpointed a genetic variant tied to an increased risk for stroke, and have also uncovered new details about an important metabolic pathway that plays a major role in several common diseases. Together, their findings may provide new clues to underlying genetic and biochemical influences in the development of stroke and cardiovascular disease, and may also help lead to new treatment strategies. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - March 20, 2014 Category: Genetics & Stem Cells Source Type: news
NIH team discovers genetic disorder causing strokes and vascular inflammation in children
National Institutes of Health researchers have identified gene variants that cause a rare syndrome of sporadic fevers, skin rashes and recurring strokes, beginning early in childhood. The team's discovery coincides with findings by an Israeli research group that identified an overlapping set of variants of the same gene in patients with a similar type of blood vessel inflammation. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - February 19, 2014 Category: Genetics & Stem Cells Source Type: news
TCGA bladder cancer study reveals potential drug targets, similarities to several cancers
Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified new potential therapeutic targets for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease. They also discovered that, at the molecular level, some subtypes of bladder cancer - also known as urothelial carcinoma - resemble subtypes of breast, head and neck and lung cancers, suggesting similar routes of development. (Source: NHGRI Press Releases)
Source: NHGRI Press Releases - January 29, 2014 Category: Genetics & Stem Cells Source Type: news
